Lei Liu, WenJie Huang, KeBing Luo, YiZhou Zeng, YunHao Shao, ZongMin Long
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To evaluate the value of semen parameters and serum InhB and INSL-3 levels in distinguishing disease severity in patients with varicocele.</p></div><div><h3>Results</h3><p>Serum INSL-3 in patients with varicocele decreased with the severity of the disease. Serum INSL-3 was positively correlated with total sperm count and frequency of normal sperm morphology. There was a weak correlation between serum InhB and semen volume, concentration, and total sperm. Patients with different disease severity were similar within the groups, with partial overlap or similarity between varicocele Grade I and Grade II, and significant differences between Grade III and Grade I and II. Semen volume, concentration, total sperm, normal sperm morphology, and serum InhB and INSL-3 levels could distinguish the degree of varicocele.</p></div><div><h3>Conclusion</h3><p>Semen parameters and the combination of serum InhB and INSL-3 levels in patients with varicocele are closely related to the severity of the disease. 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引用次数: 0
摘要
背景:精索静脉曲张是阴囊内潘品尼亚静脉丛的异常扩张,导致精子生成障碍和精子质量下降。导致精索静脉曲张相关不育症的确切病理生理机制尚未完全阐明。精索静脉曲张虽然可以治疗,但可能导致男性不育:研究男性患者精液参数、血清 InhB 和 INSL-3 水平与精索静脉曲张程度之间的关系:方法:检测血清 InhB 和 INSL-3。评估精液参数与血清 InhB 和 INSL-3 水平之间的关系。评估精液参数、血清 InhB 和 INSL-3 水平在区分精索静脉曲张患者疾病严重程度方面的价值:结果:精索静脉曲张患者的血清 INSL-3 随病情严重程度而下降。血清 INSL-3 与精子总数和精子形态正常的频率呈正相关。血清 InhB 与精液量、浓度和精子总数之间的相关性较弱。不同疾病严重程度的患者在组内相似,精索静脉曲张 I 级和 II 级之间有部分重叠或相似,III 级与 I 级和 II 级之间有显著差异。精液量、浓度、总精子数、正常精子形态以及血清 InhB 和 INSL-3 水平可区分精索静脉曲张的程度:结论:精索静脉曲张患者的精液参数以及血清 InhB 和 INSL-3 水平与疾病的严重程度密切相关。血清INSL-3有望成为早期临床干预的潜在生物标志物。
Relationship between semen parameters, serum InhB, and INSL-3 levels, and the degree of varicocele
Background
Varicocele is an abnormal expansion of the pampininias venous plexus in the scrotum, resulting in impaired sperm production and reduced sperm quality. The exact pathophysiological mechanism leading to varicocele-related infertility has not been fully elucidated. Although treatable, varicocele may lead to male infertility.
Objective
To investigate the relationship between semen parameters, serum InhB and INSL-3 levels, and the degree of varicocele in male patients.
Methods
Serum InhB and INSL-3 were detected. To evaluate the relationship between semen parameters and serum InhB and INSL-3 levels. To evaluate the value of semen parameters and serum InhB and INSL-3 levels in distinguishing disease severity in patients with varicocele.
Results
Serum INSL-3 in patients with varicocele decreased with the severity of the disease. Serum INSL-3 was positively correlated with total sperm count and frequency of normal sperm morphology. There was a weak correlation between serum InhB and semen volume, concentration, and total sperm. Patients with different disease severity were similar within the groups, with partial overlap or similarity between varicocele Grade I and Grade II, and significant differences between Grade III and Grade I and II. Semen volume, concentration, total sperm, normal sperm morphology, and serum InhB and INSL-3 levels could distinguish the degree of varicocele.
Conclusion
Semen parameters and the combination of serum InhB and INSL-3 levels in patients with varicocele are closely related to the severity of the disease. Serum INSL-3 is expected to be a potential biomarker for early clinical intervention.
期刊介绍:
CLINICS is an electronic journal that publishes peer-reviewed articles in continuous flow, of interest to clinicians and researchers in the medical sciences. CLINICS complies with the policies of funding agencies which request or require deposition of the published articles that they fund into publicly available databases. CLINICS supports the position of the International Committee of Medical Journal Editors (ICMJE) on trial registration.