Camila M. Medeiros, Carla C.M. Medeiros, Ricardo A. Olinda, Rodrigo P.T. Vianna, Monica O.S. Simões, Marília M. Medeiros, Danielle F. de Carvalho
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引用次数: 0
摘要
目的建立一个以心脏代谢指标为基础的模型,该模型可识别出患亚临床动脉粥样硬化疾病(SAD)风险较高的超重青少年:横断面研究,涉及161名体重指数≥+1 z-Score的10至19岁青少年。使用超声波评估颈动脉内膜-中膜复合厚度(IMT),以评估亚临床动脉粥样硬化疾病。评估的心脏代谢指标包括营养状况、中心脂肪率、血压、血脂、血糖以及年龄和性别。数据采用中心倾向和离散度、绝对频率和相对频率的测量方法。IMT测量值(结果变量)与其他变量(自变量)之间的关系使用皮尔逊或斯皮尔曼相关性进行评估,然后使用伽马分布多元回归模型分析IMT的预测因素。统计分析使用 SPSS 和 R 软件进行,显著性水平为 5%:结果发现,23.7%的人患有颈动脉增厚,空腹血糖异常的患病率最低。年龄和空腹血糖被认为是预测内径增大的因素,内径增大随着年龄的增长每年下降约 1%,随着血糖的升高每毫克/分升上升约 0.24%:结论:风险较高的青少年年龄较小,空腹血糖水平较高。
Fasting glucose: a cardiometabolic indicator for subclinical atherosclerosis on excess weight adolescents
Objective
To build a model based on cardiometabolic indicators that allow the identification of overweight adolescents at higher risk of subclinical atherosclerotic disease (SAD).
Methods
Cross-sectional study involving 161 adolescents with a body mass index ≥ +1 z-Score, aged 10 to 19 years. Carotid intima-media complex thickness (IMT) was evaluated using ultrasound to assess subclinical atherosclerotic disease. Cardiometabolic indicators evaluated included nutritional status, central adiposity, blood pressure, lipidic profile, glycemic profile, as well as age and sex. Data was presented using measures of central tendency and dispersion, as well as absolute and relative frequency. The relationship between IMT measurement (outcome variable) and other variables (independent variables) was assessed using Pearson or Spearman correlation, followed by multiple regression modeling with Gamma distribution to analyze predictors of IMT. Statistical analysis was performed using SPSS and R software, considering a significance level of 5 %.
Results
It was observed that 23.7 % had Carotid thickening, and the prevalence of abnormal fasting glucose was the lowest. Age and fasting glucose were identified as predictors of IMT increase, with IMT decreasing with age by approximately 1 % per year and increasing with glucose by around 0.24 % per mg/dL.
Conclusion
The adolescent at higher risk is younger with higher fasting glycemia levels.
期刊介绍:
Jornal de Pediatria is a bimonthly publication of the Brazilian Society of Pediatrics (Sociedade Brasileira de Pediatria, SBP). It has been published without interruption since 1934. Jornal de Pediatria publishes original articles and review articles covering various areas in the field of pediatrics. By publishing relevant scientific contributions, Jornal de Pediatria aims at improving the standards of pediatrics and of the healthcare provided for children and adolescents in general, as well to foster debate about health.