孟加拉国一家三甲医院类风湿关节炎患者细胞因子 IL-17、IL-4、IL-6 和 IL-12 基因多态性的相关性。

IF 2.3 Q2 RHEUMATOLOGY International Journal of Rheumatology Pub Date : 2024-02-02 eCollection Date: 2024-01-01 DOI:10.1155/2024/3728179
Taskin Jahan, Ahmed Abu Saleh, Shaheda Anwar
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引用次数: 0

摘要

类风湿性关节炎(RA)是一种慢性自身免疫性炎症疾病,其发病机制与细胞因子有关。本研究旨在调查 IL-17、IL-4、IL-6 和 IL-12 等细胞因子的基因多态性是否会影响孟加拉国人群的 RA 易感性和严重程度。这是一项横断面比较研究,包括 40 名根据 2010 年美国风湿病学会(ACR)标准确诊的 RA 患者(无其他风湿病)和 40 名健康受试者作为对比。研究采用 PCR-RFLP 方法测定了 IL-17、IL-4、IL-6 和 IL-12 细胞因子基因的多态性。患者的平均年龄为(37.22 ± 6.70)岁。其中女性 31 人,男性 9 人。平均病程为(18.11 ± 7.39)个月。研究发现,类风湿性关节炎患者的 IL-17F (7488 A/G) 多态性基因型为 GG(P = 0.006,OR = 8.56,95% CI = 1.77 - 41.33)和 IL-12B(1188/A/C)多态性的 AC(P = 0.012,OR = 3.69,95% CI = 1.43 - 9.53)和 CC(P = 0.013,OR = 7.58,95% CI = 1.56 - 36.88)基因型与疾病风险显著相关。此外,IL-17F(7488)GG 基因型和 IL-12B(1188)AC 和 CC 基因型患者的类风湿性关节炎疾病严重程度和活动参数较高。研究发现,在孟加拉国人群中,IL-4(590 C/T)和IL-6(174 G/C)基因多态性与类风湿关节炎疾病风险之间没有明显关联。细胞因子IL-17F(7488 A/G)和IL-12B(1188 A/C)的基因多态性可预测孟加拉国类风湿性关节炎患者的疾病易感性和严重程度。
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Association of Cytokine IL-17, IL-4, IL-6, and IL-12 Gene Polymorphisms in Rheumatoid Arthritis Patients in a Tertiary Care Hospital in Bangladesh.

Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease that involves cytokines in its pathogenesis. This study is aimed at investigating if gene polymorphisms in cytokines like IL-17, IL-4, IL-6, and IL-12 affect RA susceptibility and severity in the Bangladeshi population. This was a cross-sectional comparative study that included 40 diagnosed RA patients according to the American College of Rheumatology (ACR) criteria 2010, who were free from other rheumatological diseases, and 40 healthy subjects for comparison. The study used PCR-RFLP to determine the IL-17, IL-4, IL-6, and IL-12 cytokine gene polymorphisms. Patients had a mean age of 37.22 ± 6.70 years. Among the patients, 31 were female and 9 were male. The mean disease duration was 18.11 ± 7.39 months. The study found that rheumatoid arthritis patients with the IL-17F (7488 A/G) polymorphism with GG genotype (P = 0.006, OR = 8.56, 95% CI = 1.77 - 41.33) and IL-12B (1188 A/C) polymorphism with AC (P = 0.012, OR = 3.69, 95% CI = 1.43 - 9.53) and CC (P = 0.013, OR = 7.58, 95% CI = 1.56 - 36.88) genotypes were significantly associated with disease risk. Furthermore, patients with the IL-17F (7488) GG genotype and IL-12B (1188) AC and CC genotypes had higher rheumatoid arthritis disease severity and activity parameters. The study found no significant association between polymorphisms involving IL-4 (590 C/T) and IL-6 (174 G/C) genes and rheumatoid arthritis disease risk in the Bangladeshi population. Gene polymorphisms in cytokines IL-17F (7488 A/G) and IL-12B (1188 A/C) can predict disease susceptibility and severity in Bangladeshi rheumatoid arthritis patients.

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来源期刊
CiteScore
4.40
自引率
0.00%
发文量
9
审稿时长
24 weeks
期刊最新文献
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