加速性长期遗忘:从主观记忆衰退到明确的临床实体。

IF 1.6 4区 心理学 Q3 PSYCHOLOGY, DEVELOPMENTAL Aging, Neuropsychology, and Cognition Pub Date : 2024-11-01 Epub Date: 2024-02-16 DOI:10.1080/13825585.2024.2317924
Massimiliano Ruggeri, Monica Ricci, Carmela Gerace, Carlo Blundo
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引用次数: 0

摘要

主观记忆衰退(SMD)可能代表阿尔茨海默病(AD)的临床前期,有报道称癫痫性遗忘症与加速长期遗忘(ALF)有关。我们通过 RAVLT 回忆和识别以及保留 1 周后的 ROCF 回忆来研究 SMD 受试者的 ALF,并与对照组进行比较。我们对 RAVLT 和 ROCF 进行了双向方差分析,并将 EMQ 和 DASS-21 作为因素进行了逐步回归分析。延迟一周后,SMD受试者在RAVLT的回忆和识别能力上的表现明显差于对照组,但在ROCF上的表现却不明显,而且与抑郁或记忆抱怨无关。SMD患者表现出ALF,这通常与颞叶功能障碍有关,是客观评估SMD患者记忆问题的认知标志物,并能揭示通常在AD中受损的涉及颞叶结构的初始神经退行性疾病。因此,SMD 可能不再是 "主观的",而是一个特定和明确的临床实体。
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Accelerated long-term forgetting: from subjective memory decline to a defined clinical entity.

Subjective memory decline (SMD) might represent the preclinical phase of Alzheimer's disease (AD), and has been reported in epileptic amnesia associated with accelerated long-term forgetting (ALF). We investigated ALF in SMD subjects by means of RAVLT recall and recognition and ROCF recall after 1-week retention and compared with a control group. Two-way ANOVAs for RAVLT and ROCF were conducted, and stepwise regression analysis was administered considering EMQ and DASS-21 as factors. SMD subjects performed significantly worse than controls at 1-week delay on RAVLT recall and recognition, but not on ROCF, and not associated with depression or memory complaints. SMD patients showed ALF, which is usually associated with temporomesial dysfunctions, representing a cognitive marker to assess objectively memory problems in SMD, and to undisclose initial neurodegenerative disease involving temporal structures usually compromised in AD. Therefore, SMD might no longer be "subjective," but rather a specific and defined clinical entity.

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来源期刊
CiteScore
4.30
自引率
5.30%
发文量
52
期刊介绍: The purposes of Aging, Neuropsychology, and Cognition are to (a) publish research on both the normal and dysfunctional aspects of cognitive development in adulthood and aging, and (b) promote the integration of theories, methods, and research findings between the fields of cognitive gerontology and neuropsychology. The primary emphasis of the journal is to publish original empirical research. Occasionally, theoretical or methodological papers, critical reviews of a content area, or theoretically relevant case studies will also be published.
期刊最新文献
Cognitive components of aging-related increase in word-finding difficulty. Accelerated long-term forgetting: from subjective memory decline to a defined clinical entity. Naturalistic assessments in virtual reality and in real life help resolve the age-prospective memory paradox. Effects of extended practice and unitization on relational memory in older adults and neuropsychological lesion cases. Age differences in spatial memory are mitigated during naturalistic navigation.
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