体外测定环吡酮胺和特比萘芬复方制剂在治疗皮肤癣菌病中的疗效

IF 2.2 4区医学 Q3 MYCOLOGY Journal de mycologie medicale Pub Date : 2024-02-10 DOI:10.1016/j.mycmed.2024.101464

Bárbara da Costa , Bruna Pippi , Magda Chaves , Giovanna Agostineto , Alexandre Meneghello Fuentefria

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引用次数: 0

摘要

导言：皮癣病的病例越来越多，而且治疗失败的病例也越来越多，这导致医生开出了多种抗真菌药联合治疗的处方。本研究旨在评估特比萘芬和环吡酮胺这两种临床上最常用的抗真菌药在皮癣菌分离物中的相互作用。方法根据 CLSI 采用肉汤微量稀释法测定环吡酮胺和特比萘芬的最低抑菌浓度（MIC），并采用棋盘格检测法评估两种抗真菌药之间的相互作用。环吡酮胺的 mic50 值为 2.0 微克/毫升，mic90 值为 4.0 微克/毫升。结论这些结果表明，临床上广泛使用的特比萘芬与环吡酮胺联用可能不是治疗甲癣的好选择。

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In vitro determination of the combination of ciclopirox and terbinafine in the treatment of dermatophytosis

Introduction

The cases of dermatophytosis are increasing and they are associated with a higher number of therapeutic failures leading the doctor to prescribe combinations of antifungals as therapy. The objective was to evaluate the interaction of terbinafine and ciclopirox, the most commonly antifungals used in the clinic, in dermatophyte isolates.

Methodology

The minimum inhibitory concentrations (MIC) of ciclopirox and terbinafine were determined by the broth microdilution method according CLSI and the checkerboard assay was used to evaluate the interaction between the antifungal agents.

Results

For terbinafine the mic50 was 0.125 ug/mL and mic90 was 0.250 ug/mL. For ciclopirox the values were 2.0 ug/mL for mic50 and 4.0 ug/mL for mic90. No synergistic interaction was observed for the dermatophyte isolates tested.

Conclusion

These results suggest that the use of terbinafine in combination with ciclopirox, which is widely used in the clinic, may not be a good choice for the treatment of onychomycosis.

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来源期刊

Journal de mycologie medicale 医学-真菌学

CiteScore

5.10

自引率

2.80%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal de Mycologie Medicale / Journal of Medical Mycology (JMM) publishes in English works dealing with human and animal mycology. The subjects treated are focused in particular on clinical, diagnostic, epidemiological, immunological, medical, pathological, preventive or therapeutic aspects of mycoses. Also covered are basic aspects linked primarily with morphology (electronic and photonic microscopy), physiology, biochemistry, cellular and molecular biology, immunochemistry, genetics, taxonomy or phylogeny of pathogenic or opportunistic fungi and actinomycetes in humans or animals. Studies of natural products showing inhibitory activity against pathogenic fungi cannot be considered without chemical characterization and identification of the compounds responsible for the inhibitory activity. JMM publishes (guest) editorials, original articles, reviews (and minireviews), case reports, technical notes, letters to the editor and information. Only clinical cases with real originality (new species, new clinical present action, new geographical localization, etc.), and fully documented (identification methods, results, etc.), will be considered. Under no circumstances does the journal guarantee publication before the editorial board makes its final decision. The journal is indexed in the main international databases and is accessible worldwide through the ScienceDirect and ClinicalKey platforms.