用于前列腺癌治疗的脂质体:综述

Chinmaya Keshari Sahoo , Nalini Kanta Sahoo , Madhusmita Sahu
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引用次数: 0

摘要

前列腺癌是影响男性的癌症之一,它大大提高了全球男性的死亡率。前列腺癌患者可能是局部病变,也可能是晚期病变。数字直肠检查、前列腺特异性抗原分析和前列腺活检都可用于鉴别前列腺癌。癌症的发病、发展和扩散都与特定基因的突变有关。根治性前列腺切除术、消融放射治疗和积极监测都是治疗局部前列腺癌的方法。雄激素剥夺疗法(ADT)、放疗和化疗适用于转移性前列腺癌或复发的男性。与传统的癌症化疗方法相比,基于脂质体的给药技术是一种毒性低、可生物降解、生物相容性好的纳米药物。脂质体可提高抗恶性细胞药物的敏感性、特异性和在体内的持久性,从而为纳米药物的使用提供了巨大优势。脂质体制剂正在对包括前列腺癌在内的多种癌症进行临床试验。本综述介绍了脂质体的组成和类型、优缺点、制备方法、研究、临床应用、药物再利用和给药。
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Liposomes for the treatment of prostate cancer therapy: A review

One of the cancers that affect men, prostate cancer considerably raises mortality rates for males around the world. Patients with prostate cancer can have a localized or advanced form of the illness. Digital rectal examinations, prostate-specific antigen analyses, and prostate biopsies are all used to identify prostate cancer. The onset, development, and spread of cancer are all correlated with mutations in specific genes. Radical prostatectomy, ablative radiation, and active surveillance are all forms of treatment for localized prostate cancer. Androgen deprivation therapy (ADT), radiation, and chemotherapy are given to men who have metastatic prostate cancer or have experienced a relapse. When compared to traditional cancer chemotherapeutic methods, the liposome-based drug delivery technology offers less toxic, biodegradable, and biocompatible nanomedicine. Liposomes offer great advantages for use in nanomedicines by improving the sensitivity, specificity, and persistence of these anti-malignant cell agents in the body. Liposomal formulations are undergoing clinical trials of variety of cancers including prostate cancer. The present narrative review describes the composition and types of liposomes, its advantages, disadvantages, and the methods of preparation, research studies, clinical applications, drug repurposing and administration.

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来源期刊
CiteScore
4.30
自引率
0.00%
发文量
148
审稿时长
56 days
期刊介绍: Cancer Treatment and Research Communications is an international peer-reviewed publication dedicated to providing comprehensive basic, translational, and clinical oncology research. The journal is devoted to articles on detection, diagnosis, prevention, policy, and treatment of cancer and provides a global forum for the nurturing and development of future generations of oncology scientists. Cancer Treatment and Research Communications publishes comprehensive reviews and original studies describing various aspects of basic through clinical research of all tumor types. The journal also accepts clinical studies in oncology, with an emphasis on prospective early phase clinical trials. Specific areas of interest include basic, translational, and clinical research and mechanistic approaches; cancer biology; molecular carcinogenesis; genetics and genomics; stem cell and developmental biology; immunology; molecular and cellular oncology; systems biology; drug sensitivity and resistance; gene and antisense therapy; pathology, markers, and prognostic indicators; chemoprevention strategies; multimodality therapy; cancer policy; and integration of various approaches. Our mission is to be the premier source of relevant information through promoting excellence in research and facilitating the timely translation of that science to health care and clinical practice.
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