Ekaterina A. Ermakova, Yuliya A. Golubeva, Ksenia S. Smirnova, Lyubov S. Klyushova, Dmitriy G. Sheven’, Elizaveta V. Lider
{"title":"镍（II）与 1H-四氮唑-5-乙酸和低聚吡啶配合物的合成、结构表征和细胞毒性","authors":"Ekaterina A. Ermakova, Yuliya A. Golubeva, Ksenia S. Smirnova, Lyubov S. Klyushova, Dmitriy G. Sheven’, Elizaveta V. Lider","doi":"10.1007/s11243-024-00573-y","DOIUrl":null,"url":null,"abstract":"<div><p>Nickel(II) complexes of 1H-tetrazol-5-acetic acid (H<sub>2</sub>L) and oligopyridines (1,10-phenanthroline /2,2’-bipyridine derivatives) have been synthesized and characterized by physicochemical methods (elemental and thermogravimetric analysis, powder X-ray diffraction, and IR spectroscopy). The behavior of the complexes in solution was studied by UV–Vis spectroscopy, conductometry, and mass spectrometry. The stability of the complexes over 48 h in aqueous solution and in phosphate-buffered saline was demonstrated using UV–Vis spectroscopy. These compounds were investigated for their cytotoxic and cytostatic activity against HepG2 (hepatocellular carcinoma), and Hep2 (larynx carcinoma) human cancer cell lines. Cytotoxicity was also studied on human non-cancerous cell line MRC-5 (lung fibroblast). All the compounds did not show cytotoxic activity against the tested cell lines in 1–50-µM concentration range. However, compounds showed a cytostatic effect against HepG2 and Hep2 cell lines. The most pronounced cytostatic properties were found for the complex [Ni(dmphen)<sub>2</sub>L]·2C<sub>2</sub>H<sub>5</sub>OH·2H<sub>2</sub>O (<b>1</b>). In addition, we report three new crystal structures: [Ni(phen)<sub>2</sub>L]·H<sub>2</sub>O, [Ni(dmbipy)<sub>2</sub>L]·2C<sub>2</sub>H<sub>5</sub>OH, and [Ni(dmphen)<sub>2</sub>L]·2C<sub>2</sub>H<sub>5</sub>OH·2H<sub>2</sub>O, where L<sup>2–</sup> behaves as a bidentate ligand which is coordinated to the Ni(II) ion via N,O atoms.</p></div>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis, structural characterization, and cytotoxicity of nickel(II) complexes with 1H-tetrazole-5-acetic acid and oligopyridines\",\"authors\":\"Ekaterina A. Ermakova, Yuliya A. Golubeva, Ksenia S. Smirnova, Lyubov S. Klyushova, Dmitriy G. Sheven’, Elizaveta V. Lider\",\"doi\":\"10.1007/s11243-024-00573-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Nickel(II) complexes of 1H-tetrazol-5-acetic acid (H<sub>2</sub>L) and oligopyridines (1,10-phenanthroline /2,2’-bipyridine derivatives) have been synthesized and characterized by physicochemical methods (elemental and thermogravimetric analysis, powder X-ray diffraction, and IR spectroscopy). The behavior of the complexes in solution was studied by UV–Vis spectroscopy, conductometry, and mass spectrometry. The stability of the complexes over 48 h in aqueous solution and in phosphate-buffered saline was demonstrated using UV–Vis spectroscopy. These compounds were investigated for their cytotoxic and cytostatic activity against HepG2 (hepatocellular carcinoma), and Hep2 (larynx carcinoma) human cancer cell lines. Cytotoxicity was also studied on human non-cancerous cell line MRC-5 (lung fibroblast). All the compounds did not show cytotoxic activity against the tested cell lines in 1–50-µM concentration range. However, compounds showed a cytostatic effect against HepG2 and Hep2 cell lines. The most pronounced cytostatic properties were found for the complex [Ni(dmphen)<sub>2</sub>L]·2C<sub>2</sub>H<sub>5</sub>OH·2H<sub>2</sub>O (<b>1</b>). In addition, we report three new crystal structures: [Ni(phen)<sub>2</sub>L]·H<sub>2</sub>O, [Ni(dmbipy)<sub>2</sub>L]·2C<sub>2</sub>H<sub>5</sub>OH, and [Ni(dmphen)<sub>2</sub>L]·2C<sub>2</sub>H<sub>5</sub>OH·2H<sub>2</sub>O, where L<sup>2–</sup> behaves as a bidentate ligand which is coordinated to the Ni(II) ion via N,O atoms.</p></div>\",\"PeriodicalId\":1,\"journal\":{\"name\":\"Accounts of Chemical Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":16.4000,\"publicationDate\":\"2024-02-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Accounts of Chemical Research\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s11243-024-00573-y\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s11243-024-00573-y","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Synthesis, structural characterization, and cytotoxicity of nickel(II) complexes with 1H-tetrazole-5-acetic acid and oligopyridines
Nickel(II) complexes of 1H-tetrazol-5-acetic acid (H2L) and oligopyridines (1,10-phenanthroline /2,2’-bipyridine derivatives) have been synthesized and characterized by physicochemical methods (elemental and thermogravimetric analysis, powder X-ray diffraction, and IR spectroscopy). The behavior of the complexes in solution was studied by UV–Vis spectroscopy, conductometry, and mass spectrometry. The stability of the complexes over 48 h in aqueous solution and in phosphate-buffered saline was demonstrated using UV–Vis spectroscopy. These compounds were investigated for their cytotoxic and cytostatic activity against HepG2 (hepatocellular carcinoma), and Hep2 (larynx carcinoma) human cancer cell lines. Cytotoxicity was also studied on human non-cancerous cell line MRC-5 (lung fibroblast). All the compounds did not show cytotoxic activity against the tested cell lines in 1–50-µM concentration range. However, compounds showed a cytostatic effect against HepG2 and Hep2 cell lines. The most pronounced cytostatic properties were found for the complex [Ni(dmphen)2L]·2C2H5OH·2H2O (1). In addition, we report three new crystal structures: [Ni(phen)2L]·H2O, [Ni(dmbipy)2L]·2C2H5OH, and [Ni(dmphen)2L]·2C2H5OH·2H2O, where L2– behaves as a bidentate ligand which is coordinated to the Ni(II) ion via N,O atoms.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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