用于心血管再生的组织工程:支架制作简评

Thasleema Parveen Malick, Kugambikai Vangetaraman, S. Saidin, Ahmad Kafrawi Nasution
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摘要

组织工程学是工程学与基础科学的结合,旨在开发一种源自人体组织的人造器官。它涉及三大支柱的构建,包括细胞来源、支架材料和生物因子。要构建功能性人工组织工程产品,必须将这三个重要元素很好地结合和整合起来。组织工程的应用领域不断扩大,而心血管再生是组织工程的目标之一。在制造技术中,电纺丝、三维打印、模塑和脱细胞是四种常用于制造心血管组织工程支架的工程方法。心血管组织工程学兴起的目的之一,是由于目前商业化的补片或膜在心血管治疗后往往会引起并发症。本综述论文简要介绍了用于心血管再生的组织工程,重点是支架的制作。
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Tissue Engineering for Cardiovascular Regeneration: Brief Review on Scaffold Fabrication
Tissue engineering is the combination of engineering and fundamental sciences to develop an artificial organ that derived from the tissue human sources. It involves the construction of three main pillars include cell sources, scaffold materials and biological factors. These three important elements are necessary to be incorporated and integrated well, to construct a functional artificial tissue engineering product. Few applications can be associated with the expansion of tissue engineering where cardiovascular regeneration is one of the targets of tissue engineering. Among the fabrication techniques, electrospinning, three-dimensional printing, molding and decellularization, are four engineering methods that are commonly used in fabricating scaffolds for cardiovascular tissue engineering. One of the purposes of the emerging of cardiovascular tissue engineering is the limitation of current commercialized patches or membranes that often cause post-complications following the cardiovascular treatments. This review paper covering a brief introduction on the tissue engineering for cardiovascular regeneration, focusing on the scaffold fabrication.
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