由环氧酶、脂氧酶和细胞色素 P450s 介导的多不饱和脂肪酸代谢物在癌症中的病理和药理功能。

IF 12 1区 医学 Q1 PHARMACOLOGY & PHARMACY Pharmacology & Therapeutics Pub Date : 2024-02-16 DOI:10.1016/j.pharmthera.2024.108612
Yi-Wen Meng , Jun-Yan Liu
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引用次数: 0

摘要

由于在多种癌症的发病过程中,氧脂素一直被证明起着病理和/或药理作用,因此受到越来越多的关注。氧脂素是多不饱和脂肪酸通过酶和非酶途径产生的代谢产物。介导多不饱和脂肪酸代谢的酶包括但不限于脂氧合酶 (LOX)、环氧化酶 (COX)、细胞色素 P450s (CYPs) 途径以及下游酶。在此,我们从病理学和药理学方面系统地总结了氧化脂素在不同癌症中的多效应,并特别提到了酶介导的氧化脂素。我们讨论了氧脂对癌症发病、生长、侵袭和转移的具体作用,以及相关代谢酶的表达变化和相关的内在机制。此外,我们还讨论了作为癌症预防和治疗靶点的氧脂素及相关代谢酶的临床应用和潜力。我们发现,大多数氧脂素在癌症中的特定功能,尤其是其潜在机制和临床应用,值得并需要进一步研究。我们相信,对氧脂素的研究不仅能为各种癌症提供更多的治疗靶点,还能为癌症患者和健康人提供饮食指导。
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Pathological and pharmacological functions of the metabolites of polyunsaturated fatty acids mediated by cyclooxygenases, lipoxygenases, and cytochrome P450s in cancers

Oxylipins have garnered increasing attention because they were consistently shown to play pathological and/or pharmacological roles in the development of multiple cancers. Oxylipins are the metabolites of polyunsaturated fatty acids via both enzymatic and nonenzymatic pathways. The enzymes mediating the metabolism of PUFAs include but not limited to lipoxygenases (LOXs), cyclooxygenases (COXs), and cytochrome P450s (CYPs) pathways, as well as the down-stream enzymes. Here, we systematically summarized the pleiotropic effects of oxylipins in different cancers through pathological and pharmacological aspects, with specific reference to the enzyme-mediated oxylipins. We discussed the specific roles of oxylipins on cancer onset, growth, invasion, and metastasis, as well as the expression changes in the associated metabolic enzymes and the associated underlying mechanisms. In addition, we also discussed the clinical application and potential of oxylipins and related metabolic enzymes as the targets for cancer prevention and treatment. We found the specific function of most oxylipins in cancers, especially the underlying mechanisms and clinic applications, deserves and needs further investigation. We believe that research on oxylipins will provide not only more therapeutic targets for various cancers but also dietary guidance for both cancer patients and healthy humans.

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来源期刊
CiteScore
23.00
自引率
0.70%
发文量
222
审稿时长
90 days
期刊介绍: Pharmacology & Therapeutics, in its 20th year, delivers lucid, critical, and authoritative reviews on current pharmacological topics.Articles, commissioned by the editor, follow specific author instructions.This journal maintains its scientific excellence and ranks among the top 10 most cited journals in pharmacology.
期刊最新文献
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