L-[11С-Methyl]methionine 的自动合成模块：PET 中的设计、性能和效率

IF 0.9 Q4 CHEMISTRY, INORGANIC & NUCLEAR Radiochemistry Pub Date : 2024-02-19 DOI:10.1134/S1066362223060097

O. F. Kuznetsova, V. V. Orlovskaya, D. D. Vaulina, V. Yu. Obolentsev, A. S. Demyanov, R. N. Krasikova

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引用次数: 0

摘要

摘要设计了一种用于合成 L-[11C-甲基]蛋氨酸的自动化模块，L-[11C-甲基]蛋氨酸是一种著名的用于脑肿瘤成像的 PET 放射性示踪剂。该模块符合现代放射性药物生产和辐射安全的要求；得益于在 Delphi 编程环境中创建的原始程序，该模块便于合成控制（用户友好）和操作；该服务可自行维护，时间和经济成本极低。该模块可确保生产出化学纯度、放射化学纯度和对映体纯度都很高的 L-[11C-甲基]蛋氨酸，放射化学收率为 30%（基于 [11C]CO2 活性，未进行衰变校正）。

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Automated Synthesis Module for L-[11С-Methyl]methionine: Design, Performance, and Efficiency in PET

An automated module for the synthesis of L-[¹¹C-methyl]methionine, a well-known PET radiotracer for brain tumor imaging, has been designed. The module meets modern requirements for the production of radiopharmaceuticals and radiation safety; thanks to the original program created in the Delphi programming environment, module is convenient for the synthesis control (user-friendly) and operation; the service can be maintained on its own with minimal time and financial costs. The module ensures the production of L-[¹¹C-methyl]methionine with high chemical, radiochemical and enantiomeric purity and a radiochemical yield of 30% (based on [¹¹C]CO₂ activity, not decay corrected).

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来源期刊

Radiochemistry CHEMISTRY, INORGANIC & NUCLEAR-

CiteScore

1.30

自引率

33.30%

发文量

期刊介绍： Radiochemistry is a journal that covers the theoretical and applied aspects of radiochemistry, including basic nuclear physical properties of radionuclides; chemistry of radioactive elements and their compounds; the occurrence and behavior of natural and artificial radionuclides in the environment; nuclear fuel cycle; radiochemical analysis methods and devices; production and isolation of radionuclides, synthesis of labeled compounds, new applications of radioactive tracers; radiochemical aspects of nuclear medicine; radiation chemistry and after-effects of nuclear transformations.