过敏症中的组织驻留记忆 T 细胞

IF 8.4 2区 医学 Q1 ALLERGY Clinical Reviews in Allergy & Immunology Pub Date : 2024-02-01 Epub Date: 2024-02-21 DOI:10.1007/s12016-024-08982-8
Bojin Long, Shican Zhou, Yawen Gao, Kai Fan, Ju Lai, Chunyan Yao, Jingwen Li, Xiayue Xu, Shaoqing Yu
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摘要

组织驻留记忆 T 细胞(TRM)是记忆 T 细胞群中的一个独特亚群,是抵抗外周非淋巴组织(包括呼吸道、肠道和皮肤)中入侵病原体和抗原的先锋。值得注意的是,TRM 细胞适应每个组织的特定微环境,主要保持无柄状态,具有独特的表型和功能属性。它们的作用是确保持续的免疫监视和保护。最近的研究结果表明,TRM 细胞在调节过敏性疾病(如过敏性鼻炎、哮喘和皮炎)的适应性免疫反应中起着关键作用。全面了解 TRM 细胞在过敏性疾病中的参与对过敏预防和治疗具有深远的意义。这篇综述全面探讨了TRM细胞的表型特征、发育机制和功能作用,重点研究了它们与过敏性疾病之间错综复杂的关系。
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Tissue-Resident Memory T Cells in Allergy.

Tissue-resident memory T (TRM) cells constitute a distinct subset within the memory T cell population, serving as the vanguard against invading pathogens and antigens in peripheral non-lymphoid tissues, including the respiratory tract, intestines, and skin. Notably, TRM cells adapt to the specific microenvironment of each tissue, predominantly maintaining a sessile state with distinctive phenotypic and functional attributes. Their role is to ensure continuous immunological surveillance and protection. Recent findings have highlighted the pivotal contribution of TRM cells to the modulation of adaptive immune responses in allergic disorders such as allergic rhinitis, asthma, and dermatitis. A comprehensive understanding of the involvement of TRM cells in allergic diseases bears profound implications for allergy prevention and treatment. This review comprehensively explores the phenotypic characteristics, developmental mechanisms, and functional roles of TRM cells, focusing on their intricate relationship with allergic diseases.

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来源期刊
CiteScore
22.30
自引率
1.10%
发文量
58
审稿时长
6-12 weeks
期刊介绍: Clinical Reviews in Allergy & Immunology is a scholarly journal that focuses on the advancement of clinical management in allergic and immunologic diseases. The journal publishes both scholarly reviews and experimental papers that address the current state of managing these diseases, placing new data into perspective. Each issue of the journal is dedicated to a specific theme of critical importance to allergists and immunologists, aiming to provide a comprehensive understanding of the subject matter for a wide readership. The journal is particularly helpful in explaining how novel data impacts clinical management, along with advancements such as standardized protocols for allergy skin testing and challenge procedures, as well as improved understanding of cell biology. Ultimately, the journal aims to contribute to the improvement of care and management for patients with immune-mediated diseases.
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