Zainab Alimoradi , Farideh Kazemi , Azita Tiznobeik , Mark D. Griffiths , Seyyedeh Zahra Masoumi , Soodabeh Aghababaei
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引用次数: 0
摘要
以往关于维生素 D 对子痫前期发病率影响的研究结果并不一致。因此，本综述的主要目的是确定孕期补充维生素 D 对子痫前期风险的影响。我们检索了从开始到 2023 年 6 月 10 日的五个主要科学数据库。检索了采用随机对照试验设计的研究。为了评估所选研究的方法学质量，使用了科克伦工具检查表（CTC）。选择随机效应模型作为组合模型。统计异质性采用标准 χ 检验进行评估，异质性强度采用 。计算效应大小指标，包括风险比（RR）、风险差异（RD）和治疗所需人数（NNT），并估计 95% 的置信区间。系统综述和荟萃分析共纳入了 19 项研究。与对照组相比，干预组先兆子痫的总RR为0.61 (95% CI, 0.47 to 0.78; =14.4%; χ=23.37; =0.27; tau=0.05)，表明先兆子痫的风险降低了39%。与对照组相比，干预组先兆子痫的汇总RD为-0.03 (95% CI: -0.05 to -0.01; =45.5%; χ=36.68; =0.01; tau=0.0008)，接受维生素D补充剂的妇女的先兆子痫风险差异比对照组低3%。NNT为29（95% CI：20至52）。补充维生素D可明显减少孕期子痫前期的发生。
The effect of vitamin D supplementation in pregnancy on the incidence of preeclampsia: A systematic review and meta-analysis
Introduction
The results of previous studies regarding the effect of vitamin D on the incidence of preeclampsia are inconsistent. Therefore, the primary objective of the present review was to determine the effect of vitamin D supplementation during pregnancy on the risk of preeclampsia.
Methods
Five major scientific databases were searched from inception to June 10, 2023. Studies with randomized controlled trial designs were identified. To assess the methodological quality of the selected studies, the Cochrane Tool Checklist (CTC) was used. The random effect model was chosen as a combination model. Statistical heterogeneity was evaluated using the standard χ2 test, and the intensity of heterogeneity was calculated using I2. Effect size indicators including risk ratio (RR), risk difference (RD), and number needed to treat (NNT) were calculated with estimated 95 % confidence intervals.
Results
Nineteen studies were included in the systematic review and meta-analysis. The pooled RR of preeclampsia in the intervention group compared to the control group was 0.61 (95 % CI, 0.47 to 0.78; I2=14.4 %; χ2=23.37; p = 0.27; tau2=0.05), and indicated a 39 % reduction in the risk of preeclampsia. The pooled RD of preeclampsia in the intervention group compared to the control group was -0.03 (95 % CI: -0.05 to -0.01; I2=45.5 %; χ2=36.68; p = 0.01; tau2=0.0008) and the difference in the risk of preeclampsia among women who received vitamin D supplements was 3 % less than the control group. The NNT was 29 (95 % CI: 20 to 52).
Conclusion
Vitamin D supplementation significantly reduces preeclampsia during pregnancy.
期刊介绍：
The European Journal of Integrative Medicine (EuJIM) considers manuscripts from a wide range of complementary and integrative health care disciplines, with a particular focus on whole systems approaches, public health, self management and traditional medical systems. The journal strives to connect conventional medicine and evidence based complementary medicine. We encourage submissions reporting research with relevance for integrative clinical practice and interprofessional education.
EuJIM aims to be of interest to both conventional and integrative audiences, including healthcare practitioners, researchers, health care organisations, educationalists, and all those who seek objective and critical information on integrative medicine. To achieve this aim EuJIM provides an innovative international and interdisciplinary platform linking researchers and clinicians.
The journal focuses primarily on original research articles including systematic reviews, randomized controlled trials, other clinical studies, qualitative, observational and epidemiological studies. In addition we welcome short reviews, opinion articles and contributions relating to health services and policy, health economics and psychology.
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