肺唾液腺肿瘤--透明细胞癌：文献综述

IF 2.4 3区医学 Q2 PATHOLOGY Diagnostic Pathology Pub Date : 2024-02-22 DOI:10.1186/s13000-024-01460-x

Xinyuan Wang, Shumin Hu, Hongyang Lu

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引用次数: 0

摘要

原发性肺透明细胞癌（HCCC）是一种非常罕见的肺部肿瘤，占所有原发性肺部肿瘤的比例不到 0.09%，而且没有特定的流行病学。正确诊断需要进行影像学、实验室、病理学、免疫组化和分子检查。肺 HCCC 最典型的特征是透明细胞成分，基质清晰。此外，t(12;22)(q13;q12)导致的融合基因 EWSR1::ATF1 对肺 HCCC 的病理诊断至关重要。肺 HCCC 的主要治疗方法是手术。本综述重点介绍肺部 HCCC 的病理特征、免疫组化检查、突变分析和治疗。

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Pulmonary salivary gland tumor–hyalinizing clear cell carcinoma: a literature review

Primary pulmonary hyalinizing clear cell carcinoma (HCCC) is a very rare lung tumor that accounts for less than 0.09% of all primary lung tumors and has no specific epidemiology. The correct diagnosis requires imaging, laboratory, pathological, immunohistochemical, and molecular examination. The most typical feature of pulmonary HCCC is the clear cell component with clear stroma. In addition, the fusion gene EWSR1::ATF1 due to t(12;22)(q13;q12) is essential for the pathological diagnosis of pulmonary HCCC. The main treatment for pulmonary HCCC is surgery. This review focus on the pathological features, immunohistochemical examination, mutation analysis and treatment of pulmonary HCCC.

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来源期刊

Diagnostic Pathology 医学-病理学

CiteScore

4.60

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Diagnostic Pathology is an open access, peer-reviewed, online journal that considers research in surgical and clinical pathology, immunology, and biology, with a special focus on cutting-edge approaches in diagnostic pathology and tissue-based therapy. The journal covers all aspects of surgical pathology, including classic diagnostic pathology, prognosis-related diagnosis (tumor stages, prognosis markers, such as MIB-percentage, hormone receptors, etc.), and therapy-related findings. The journal also focuses on the technological aspects of pathology, including molecular biology techniques, morphometry aspects (stereology, DNA analysis, syntactic structure analysis), communication aspects (telecommunication, virtual microscopy, virtual pathology institutions, etc.), and electronic education and quality assurance (for example interactive publication, on-line references with automated updating, etc.).