Monika Habekova, Danica Valkovicova Stanekova, Maria Takacova, Alexandra Kovarova
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引用次数: 0
摘要
研究目的本研究旨在概述2017年至2018年间在斯洛伐克流行的HIV-1亚型，并评估HIV耐药株的传播风险：斯洛伐克艾滋病疫情的特点是新感染者和原有感染者的发病率较低，菌株异质性略高：分析了2017年至2018年间110名新诊断为HIV感染者的部分HIV pol基因序列：基因型分析表明，零星出现的突变与艾滋病毒对抗逆转录病毒疗法（ART）的耐药性有关。发现HIV-1 B亚型占主导地位（84.55%），主要与男男性行为者（MSM）有关。共发现 18 人（15.45%）感染了 HIV-1 非 B 亚型：这些数据表明，耐药 HIV 株传播的风险很小，HIV-1 亚型的多样性略有上升。2017-2018年期间，HIV-1 B亚型仍是斯洛伐克最流行的病毒（表2，图2，参考文献37）。
Characterization of HIV-1 subtypes and drug resistance mutations in Slovakia: update 2017-2018.
Objectives: This study aimed to provide an overview on the HIV-1 subtypes circulating in Slovakia between 2017 and 2018 and to evaluate the risk of transmission of HIV‑resistant strains.
Background: The HIV epidemic in Slovakia is characterised by low incidence of new and pre-existing infections and a slightly elevated level of strain heterogeneity.
Methods: Partial HIV pol gene sequences of 110 individuals newly diagnosed with HIV between 2017 and 2018 were analysed.
Results: The genotypic analysis revealed sporadic occurrence of mutations linked to HIV resistance to antiretroviral therapy (ART). The HIV-1 B subtype has been found as predominant (84.55 %) and primarily linked to men who have sex with men (MSM). A total of eighteen individuals (15.45 %) were found to be infected with HIV-1 non-B subtypes.
Conclusion: The data suggest a minimal risk of a resistant HIV strain transmission and a marginal rise of HIV-1 subtypes´ diversity. The HIV-1 B subtype remains the most prevalent in the period 2017-2018 in Slovakia (Tab. 2, Fig. 2, Ref. 37).
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The international biomedical journal - Bratislava Medical Journal
– Bratislavske lekarske listy (Bratisl Lek Listy/Bratisl Med J) publishes
peer-reviewed articles on all aspects of biomedical sciences, including
experimental investigations with clear clinical relevance, original clinical
studies and review articles.
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