产前接触全氟和多氟烷基物质与婴儿人体测量的关系:前瞻性队列研究

IF 4.5 2区 医学 Q1 INFECTIOUS DISEASES International journal of hygiene and environmental health Pub Date : 2024-02-23 DOI:10.1016/j.ijheh.2024.114339
Jincan Li , Xiujuan Su , Yan Zhou , Honglei Ji , Zhenzhen Xie , Songlin Sun , Ziliang Wang , Wei Yuan , Maohua Miao , Hong Liang
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引用次数: 0

摘要

背景全氟和多氟烷基物质(PFAS)是一组具有潜在内分泌干扰作用的合成有机化学物质,在实验和流行病学研究中都发现它们会损害后代的身体发育。我们的目的是研究产前接触 PFAS 对重复测量婴儿多项人体测量指标的影响。根据世界卫生组织(WHO)的儿童生长标准,我们计算了婴儿出生、6 个月和 12 个月时的体重年龄比 (WAZ)、体重身长比 (WLZ)、头围年龄比 (HCZ)、臂围年龄比 (ACZ)、肱三头肌皮褶年龄比 (TSZ) 和肩胛下皮褶年龄比 (SSZ) 等人体测量指标的 z 值。共纳入了 964 对母婴。为了研究产前PFAS浓度与各时间点人体测量指标之间的关系,我们进行了多变量线性回归。使用广义估计方程 (GEE) 模型检验了 PFAS 暴露对人体测量指标重复测量的纵向影响。结果在GEE模型中,高三分位组的全氟十二酸(PFDoA)与WAZ/WLZ的增加相关,β值(95%置信区间(CI))分别为0.12(0.00,0.23)和0.18(0.03,0.32)。全氟壬酸 (PFNA) 与中三等分组和高三等分组的 ACZ 增加有关。BKMR模型还显示,全氟辛烷磺酸混合物与整个婴儿期WAZ/WLZ的增加有关,对女性的影响更深。同时,高三等分组中的全氟辛酸(PFOA)浓度与男性 WAZ、WLZ 和 HCZ 的降低呈反向关系。结论 产前接触全氟辛酸(PFNA 和 PFDoA)与婴儿(尤其是女婴)体重增加有关,而产前接触全氟辛酸与男婴体重、头围和臂围减少有关。研究结果表明,产前接触全氟辛烷磺酸可能会损害后代的生长轨迹。
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Association between prenatal exposure to per- and polyfluoroalkyl substances and infant anthropometry: A prospective cohort study

Background

Per- and polyfluoroalkyl substances (PFAS) are a group of synthetic organic chemicals with potential endocrine-disrupting effects, and have been found to impair the physical growth of offspring in both experimental and epidemiological studies. We aimed to investigate the effects of prenatal PFAS exposure on repeated measurements of multiple anthropometric indicators in infants.

Method

PFAS were measured in serum samples collected from pregnant women at 12–16 gestational weeks. We calculated z-scores for the weight-for-age (WAZ), weight-for-length (WLZ), head circumference-for-age (HCZ), arm circumference-for-age (ACZ), triceps skinfold-for-age (TSZ), and subscapular skinfold-for-age (SSZ) at birth, 6 months, and 12 months of age according to the child growth standards of the World Health Organization (WHO) for anthropometric indicators. A total of 964 mother–infant pairs were included. A multivariate linear regression was performed to examine the associations between prenatal PFAS concentrations and anthropometric indicators at each time point. A generalized estimating equation (GEE) model was used to examine the longitudinal effects of PFAS exposure on repeated measurements of anthropometric indicators. Ultimately, a Bayesian kernel machine regression (BKMR) model was used to assess the joint effects of the PFAS mixture on anthropometric indicators.

Results

In GEE models, perfluorododecanoic acid (PFDoA) in the high tertile group was associated with increased WAZ/WLZ, with β values (95% confidence intervals (CI)) of 0.12 (0.00, 0.23) and 0.18 (0.03, 0.32), respectively. Perfluorononanoic acid (PFNA) was associated with increased ACZ in the middle and high tertile groups. The BKMR models also presented the associations of the PFAS mixture with increased WAZ/WLZ throughout infancy, with more profound effects in females. Meanwhile, a pattern of inverse associations was observed between the perfluorooctanoic acid (PFOA) concentrations in the high tertile group and decreased WAZ, WLZ, and HCZ in males. In addition, the associations between PFAS and increased TSZ/SSZ at birth were identified by both linear regression and BKMR models.

Conclusion

Prenatal PFAS exposure (PFNA and PFDoA) was associated with increased infant anthropometry, especially in female infants, while prenatal PFOA exposure was associated with decreased weight, and head and arm circumference in male infants. The findings indicate that prenatal PFAS exposure may impair the growth trajectory of offspring.

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来源期刊
CiteScore
11.50
自引率
5.00%
发文量
151
审稿时长
22 days
期刊介绍: The International Journal of Hygiene and Environmental Health serves as a multidisciplinary forum for original reports on exposure assessment and the reactions to and consequences of human exposure to the biological, chemical, and physical environment. Research reports, short communications, reviews, scientific comments, technical notes, and editorials will be peer-reviewed before acceptance for publication. Priority will be given to articles on epidemiological aspects of environmental toxicology, health risk assessments, susceptible (sub) populations, sanitation and clean water, human biomonitoring, environmental medicine, and public health aspects of exposure-related outcomes.
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