神经元铁变态反应的驱动因素

IF 13 1区 生物学 Q1 CELL BIOLOGY Trends in Cell Biology Pub Date : 2024-07-01 Epub Date: 2024-02-23 DOI:10.1016/j.tcb.2024.01.010
Julie Jacquemyn, Isha Ralhan, Maria S Ioannou
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引用次数: 0

摘要

铁中毒是一种铁依赖性细胞死亡的氧化形式,其特点是膜上脂质过氧化物的积累。铁和含有多不饱和脂肪酸的脂质对这一过程至关重要。铁变态反应是多种神经系统疾病的核心,也是大脑(尤其是神经元)中铁和多不饱和脂肪酸代谢平衡的重要性的基础。在此,我们将探讨神经元生理机能与铁和过氧化脂质积累之间的潜在联系、神经元保护自身免受铁氧化的机制,以及神经退行性疾病中致病蛋白沉积与铁氧化之间的关系。我们提出,神经元独特的生理结构使其特别容易受到铁氧化作用的影响。
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Driving factors of neuronal ferroptosis.

Ferroptosis is an oxidative form of iron-dependent cell death characterized by the accumulation of lipid peroxides on membranes. Iron and lipids containing polyunsaturated fatty acids are essential for this process. Ferroptosis is central to several neurological diseases and underlies the importance of balanced iron and polyunsaturated fatty acid metabolism in the brain, particularly in neurons. Here, we reflect on the potential links between neuronal physiology and the accumulation of iron and peroxidated lipids, the mechanisms neurons use to protect themselves from ferroptosis, and the relationship between pathogenic protein deposition and ferroptosis in neurodegenerative disease. We propose that the unique physiology of neurons makes them especially vulnerable to ferroptosis.

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来源期刊
Trends in Cell Biology
Trends in Cell Biology 生物-细胞生物学
CiteScore
32.00
自引率
0.50%
发文量
160
审稿时长
61 days
期刊介绍: Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.
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