非酒精性脂肪肝的代谢紊乱：早期诊断和预后标志物的机遇。

IF 2.2 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Current molecular medicine Pub Date : 2024-02-22 DOI:10.2174/0115665240269082240213115711

Verma Abhinav, Rishabh Mittal, Mathiyazhagan Navaneethakannan, Ahirwar Sonu Singh, Mukherjee Sukhes, Kotnis Ashwin

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引用次数: 0

摘要

非酒精性脂肪肝是一种全球流行的疾病，如不及早发现，病情会迅速恶化。目前，尚无可用于非酒精性脂肪肝早期诊断和预后的公认标志物。本综述描述了非酒精性脂肪肝中脂类、碳水化合物和氨基酸等主要代谢途径的失调。它建议，测量凝血酶原、TyG 指数、不对称二甲基精氨酸、LAL-A、GLP-1、FGF-21 和 GSG 指数的水平是早期诊断非酒精性脂肪肝的潜在标志物。单一标记物可能并不能指示早期非酒精性脂肪肝，因此有必要进一步开展大规模研究，探讨凝血酶原-2、甘油三酯-葡萄糖指数和 FGF-21 水平与非酒精性脂肪肝的相关性。

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Metabolic Derangement in Non-Alcoholic Fatty Liver Disease: Opportunities for Early Diagnostic and Prognostic Markers.

Non-alcoholic fatty liver disease is a globally prevalent disorder that can rapidly progress if not detected early. Currently, no accepted markers exist for early diagnosis and prognosis of NAFLD. This review describes derangement in major metabolic pathways of lipid, carbohydrate, and amino acids in NAFLD. It suggests that measuring levels of thrombospondin, TyG index, asymmetric dimethylarginine, LAL-A, GLP-1, FGF-21, and GSG index are potential markers for early diagnosis of NAFLD. A single marker may not indicate early NAFLD, and further large-scale studies on correlating levels of Thrombospondin-2, triglyceride-glucose index, and FGF-21 with NAFLD are warranted.

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来源期刊

Current molecular medicine 医学-医学：研究与实验

CiteScore

5.00

自引率

4.00%

发文量

141

审稿时长

4-8 weeks

期刊介绍： Current Molecular Medicine is an interdisciplinary journal focused on providing the readership with current and comprehensive reviews/ mini-reviews, original research articles, short communications/letters and drug clinical trial studies on fundamental molecular mechanisms of disease pathogenesis, the development of molecular-diagnosis and/or novel approaches to rational treatment. The reviews should be of significant interest to basic researchers and clinical investigators in molecular medicine. Periodically the journal invites guest editors to devote an issue on a basic research area that shows promise to advance our understanding of the molecular mechanism(s) of a disease or has potential for clinical applications.