3岁儿童脊柱星形母细胞瘤,MN1改变:不常见部位的不常见肿瘤

IF 1.3 4区 医学 Q4 CLINICAL NEUROLOGY Neuropathology Pub Date : 2024-08-01 Epub Date: 2024-02-26 DOI:10.1111/neup.12965
Arun Kumar Panda, Sumanta Das, Anuj Singh, Sandeep Vaishya, Rakesh Kumar Gupta, Mehar Chand Sharma, Sunita Ahlawat
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引用次数: 0

摘要

星形母细胞瘤是一种不常见的环形胶质瘤,主要累及大脑半球。其特征性分子改变是脑膜瘤(平衡易位紊乱)1(MN1)重排。由于低度和高度肿瘤都有可能发生,因此世界卫生组织并没有给出明确的分级。脊柱肿瘤极为罕见;迄今为止,文献中仅报道过三例。当肿瘤出现在不寻常的位置时,如我们的病例,警惕的显微镜检查和辅助检查有助于诊断。由于该肿瘤的治疗方法各不相同,且尚未明确确立,因此必须及时将其与类似肿瘤区分开来。
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Spinal astroblastoma, MN1 altered in 3-year-old child: An uncommon tumor at an unusual site.

Astroblastoma is an uncommon circumscribed glial tumor mostly involving the cerebral hemisphere. The characteristic molecular alteration is meningioma (disrupted in balanced translocation) 1 (MN1) rearrangement. No definite World Health Organization grade has been assigned as both low- and high-grade tumors are known to occur. Tumors in the spine are extremely rare; to date only three cases have been reported in the literature. A vigilant microscopy and ancillary testing aid in diagnosis when the tumors present in unusual locations, as in our case. The prompt differentiation of this tumor from its mimickers is a mandate as modalities of management are different and not clearly established.

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来源期刊
Neuropathology
Neuropathology 医学-病理学
CiteScore
4.10
自引率
4.30%
发文量
105
审稿时长
6-12 weeks
期刊介绍: Neuropathology is an international journal sponsored by the Japanese Society of Neuropathology and publishes peer-reviewed original papers dealing with all aspects of human and experimental neuropathology and related fields of research. The Journal aims to promote the international exchange of results and encourages authors from all countries to submit papers in the following categories: Original Articles, Case Reports, Short Communications, Occasional Reviews, Editorials and Letters to the Editor. All articles are peer-reviewed by at least two researchers expert in the field of the submitted paper.
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