软组织肉瘤良性淋巴结和转移性淋巴结的鉴别。

IF 4.2 3区 医学 Q2 ONCOLOGY Clinical & Experimental Metastasis Pub Date : 2024-04-01 Epub Date: 2024-02-29 DOI:10.1007/s10585-024-10273-7
Anton Burkhard-Meier, Vindi Jurinovic, Luc M Berclaz, Markus Albertsmeier, Hans Roland Dürr, Alexander Klein, Thomas Knösel, Dorit Di Gioia, Lena M Unterrainer, Nina-Sophie Schmidt-Hegemann, Jens Ricke, Michael von Bergwelt-Baildon, Wolfgang G Kunz, Lars H Lindner
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引用次数: 0

摘要

在软组织肉瘤(STS)患者中,淋巴结转移(LNM)的发生率不到 5%,这表明病程具有侵袭性。分期成像中的可疑淋巴结(LN)是多学科肿瘤委员会经常讨论的话题。需要有预测性标志物来帮助对 STS 患者进行分层并改善治疗。在这项研究中,我们回顾了 56 名在放射学上有疑似淋巴结并随后接受了组织学检查的 STS 患者。对良性(26 例)和转移性(30 例)LN 患者的临床、实验室和影像学参数进行了分析。与良性 LN 患者相比,LNM 患者的短轴直径(SAD)和长轴直径(LAD)明显更大(中位 22.5 毫米对 14 毫米,P<0.05)。
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Differentiation of benign and metastatic lymph nodes in soft tissue sarcoma.

Lymph node metastasis (LNM) occurs in less than 5% of soft tissue sarcoma (STS) patients and indicates an aggressive course of disease. Suspicious lymph nodes (LN) in staging imaging are a frequent topic of discussion in multidisciplinary tumor boards. Predictive markers are needed to facilitate stratification and improve treatment of STS patients. In this study, 56 STS patients with radiologically suspicious and subsequently histologically examined LN were reviewed. Patients with benign (n = 26) and metastatic (n = 30) LN were analyzed with regard to clinical, laboratory and imaging parameters. Patients with LNM exhibited significantly larger short axis diameter (SAD) and long axis diameter (LAD) vs. patients with benign LN (median 22.5 vs. 14 mm, p < 0.001 and median 29.5 vs. 21 mm, p = 0.003, respectively). Furthermore, the presence of central necrosis and high maximal standardized uptake value (SUVmax) in FDG-PET-CT scans were significantly associated with LNM (60 vs. 11.5% of patients, p < 0.001 and median 8.59 vs. 3.96, p = 0.013, respectively). With systemic therapy, a slight median size regression over time was observed in both metastatic and benign LN. Serum LDH and CRP levels were significantly higher in patients with LNM (median 247 vs. 187.5U/L, p = 0.005 and 1.5 vs. 0.55 mg/dL, p = 0.039, respectively). This study shows significant associations between LNM and imaging features as well as laboratory parameters of STS patients. The largest SAD, SUVmax in FDG-PET-CT scan, the presence of central necrosis, and high serum LDH level are the most important parameters to distinguish benign from metastatic LNs.

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来源期刊
CiteScore
7.80
自引率
5.00%
发文量
55
审稿时长
12 months
期刊介绍: The Journal''s scope encompasses all aspects of metastasis research, whether laboratory-based, experimental or clinical and therapeutic. It covers such areas as molecular biology, pharmacology, tumor biology, and clinical cancer treatment (with all its subdivisions of surgery, chemotherapy and radio-therapy as well as pathology and epidemiology) insofar as these disciplines are concerned with the Journal''s core subject of metastasis formation, prevention and treatment.
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