氟苯尼考的尿排泄及其治疗犬尿路感染的潜力。

IF 1.5 4区 农林科学 Q3 PHARMACOLOGY & PHARMACY Journal of veterinary pharmacology and therapeutics Pub Date : 2024-02-29 DOI:10.1111/jvp.13434
Kate S. KuKanich, Elayna E. Anderson, Astrid D. Carcamo Tzic, Butch KuKanich
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引用次数: 0

摘要

为了探索氟苯尼考治疗尿路感染的潜力,我们对氟苯尼考在犬尿液中的排泄量进行了评估。九只健康的雄性纯种比格犬和四只健康的客户饲养的狗分别口服了一次剂量为 20 毫克/千克的氟苯尼考(300 毫克/毫升肠外溶液)和食物。据报道,尽管氟苯尼考的味道很苦,但仍有 7/9 只比格犬和 4/4 只客户饲养的狗完全摄入了氟苯尼考,并进行了登记;观察到了流涎(n = 1)和摇头(n = 3)现象。最后测得的尿液中氟苯尼考浓度各不相同:比格犬(0.23-3.19 微克/毫升)、八哥犬(3.01 微克/毫升)、英国赛特犬(21.29 微克/毫升)、灰猎犬(32.68 微克/毫升)和标准贵宾犬(13.00 微克/毫升)。比格犬和八哥犬的尿液半衰期相似,为 0.75-1.39 小时,而英国猎犬、灰猎犬和标准贵宾犬的半衰期为 1.70-1.82 小时。大型犬在 12 小时后的尿液中氟苯尼考的浓度超过 8 微克/毫升(野生型临界值),而比格犬和八哥犬的尿液中氟苯尼考的浓度仅为 1 微克/毫升(野生型临界值)。
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Florfenicol urinary excretion and its potential for treating canine urinary tract infections

The canine urinary excretion of florfenicol was evaluated to explore its potential for treating urinary tract infections. Nine healthy male intact purpose-bred Beagles and four healthy client-owned dogs each received a single oral dose of florfenicol 20 mg/kg (300 mg/mL parenteral solution) with food. All voluntary urinations were collected for 12 h. Although florfenicol is reportedly bitter tasting, 7/9 Beagles and 4/4 client-owned dogs completely ingested the florfenicol and were enrolled; salivation (n = 1) and headshaking (n = 3) were observed. The last measured urine florfenicol concentrations were variable: Beagles (0.23–3.19 mcg/mL), Pug (3.01 mcg/mL) English Setter (21.29 mcg/mL), Greyhound (32.68 mcg/mL), and Standard Poodle (13.00 mcg/mL). Urine half-life was similar for the Beagles and the Pug, 0.75–1.39 h, whereas the half-life was 1.70–1.82 h for the English Setter, Greyhound, and Standard Poodle. Larger breed dogs exceeded 8 mcg/mL florfenicol (wild-type cutoff) in their urine at 12 h, whereas the Beagles and Pug had <8 mcg/mL; it is unclear if this is an individual, breed, or size difference. These data suggest oral florfenicol may need to be administered q6-12h for canine urinary tract infections, but further data are needed (more enrolled dogs, multiple-dose regimens) before considering clinical trials or breed-specific differences.

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来源期刊
CiteScore
3.10
自引率
15.40%
发文量
69
审稿时长
8-16 weeks
期刊介绍: The Journal of Veterinary Pharmacology and Therapeutics (JVPT) is an international journal devoted to the publication of scientific papers in the basic and clinical aspects of veterinary pharmacology and toxicology, whether the study is in vitro, in vivo, ex vivo or in silico. The Journal is a forum for recent scientific information and developments in the discipline of veterinary pharmacology, including toxicology and therapeutics. Studies that are entirely in vitro will not be considered within the scope of JVPT unless the study has direct relevance to the use of the drug (including toxicants and feed additives) in veterinary species, or that it can be clearly demonstrated that a similar outcome would be expected in vivo. These studies should consider approved or widely used veterinary drugs and/or drugs with broad applicability to veterinary species.
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