钙化性主动脉瓣疾病的体内和体外模型。

IF 4 Q2 CELL & TISSUE ENGINEERING Cell Regeneration Pub Date : 2024-03-01 DOI:10.1186/s13619-024-00189-8
Zijin Zhu, Zhirong Liu, Donghui Zhang, Li Li, Jianqiu Pei, Lin Cai
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引用次数: 0

摘要

主动脉瓣钙化病(CAVD)是老年人最常见的瓣膜性心脏病。目前,没有任何药物干预措施能有效逆转或预防 CAVD,因此瓣膜置换术成为主要的治疗手段。数十年来的广泛研究促进了动物和体外细胞模型的建立,这有助于加深对 CAVD 病理生理进展和内在机制的理解。在这篇综述中,我们全面总结和分析了研究瓣膜钙化的常用模型的优势和局限性。我们特别强调了三维培养技术的进步,这种技术可以复制瓣膜结构的复杂性。此外,我们还深入探讨了推进 CAVD 体内和体外模型研究的前瞻性建议。
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Models for calcific aortic valve disease in vivo and in vitro.

Calcific Aortic Valve Disease (CAVD) is prevalent among the elderly as the most common valvular heart disease. Currently, no pharmaceutical interventions can effectively reverse or prevent CAVD, making valve replacement the primary therapeutic recourse. Extensive research spanning decades has contributed to the establishment of animal and in vitro cell models, which facilitates a deeper understanding of the pathophysiological progression and underlying mechanisms of CAVD. In this review, we provide a comprehensive summary and analysis of the strengths and limitations associated with commonly employed models for the study of valve calcification. We specifically emphasize the advancements in three-dimensional culture technologies, which replicate the structural complexity of the valve. Furthermore, we delve into prospective recommendations for advancing in vivo and in vitro model studies of CAVD.

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来源期刊
Cell Regeneration
Cell Regeneration Biochemistry, Genetics and Molecular Biology-Cell Biology
CiteScore
5.80
自引率
0.00%
发文量
42
审稿时长
35 days
期刊介绍: Cell Regeneration aims to provide a worldwide platform for researches on stem cells and regenerative biology to develop basic science and to foster its clinical translation in medicine. Cell Regeneration welcomes reports on novel discoveries, theories, methods, technologies, and products in the field of stem cells and regenerative research, the journal is interested, but not limited to the following topics: ◎ Embryonic stem cells ◎ Induced pluripotent stem cells ◎ Tissue-specific stem cells ◎ Tissue or organ regeneration ◎ Methodology ◎ Biomaterials and regeneration ◎ Clinical translation or application in medicine
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