[皮肤病学中的转化医学--进一步促进牛皮癣研究]。

Harefuah Pub Date : 2024-02-01
Shani Fisher, Michael Ziv
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引用次数: 0

摘要

简介银屑病是一种慢性炎症性皮肤病,全世界约有 2%-3% 的人患有这种疾病。转化医学专注于治疗和分析由转化因素引起的疾病,在银屑病研究领域的重要性日益凸显。本综述旨在展示当前有关转化医学在治疗和了解银屑病方面作用的文献。我们发现,蛋白激酶和细胞因子等转化因子在银屑病的发生和发展过程中起着关键作用。此外,目前治疗银屑病的方法,如生物制剂,就是针对这些转化因子来减轻炎症和改善皮肤状况的。此外,研究表明,转化相关基因的遗传变异也会导致银屑病的发生。这凸显了转化医学在了解银屑病的基本机制和开发治疗这种使人衰弱的疾病的越来越有效的方法方面的重要性。
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[TRANSLATIONAL MEDICINE IN DERMATOLOGY- FURTHER PROMOTING PSORIASIS RESEARCH].

Introduction: Psoriasis is a chronic inflammatory skin disorder that affects approximately 2-3% of the population worldwide. Translational medicine, which focuses on treating and analyzing diseases caused by translational factors, is becoming increasingly relevant in the field of psoriasis research. This review aims to display the current literature on the role of translational medicine in the treatment and understanding of psoriasis. We found that translational factors such as protein kinases and cytokines play a key role in the development and progression of psoriasis. Additionally, current treatments for psoriasis, such as biologics, target these translational factors to reduce inflammation and improve skin condition. Furthermore, studies have shown that genetic variations in translational-related genes can also contribute to the development of psoriasis. This highlights the importance of translational medicine in understanding the underlying mechanisms of psoriasis and developing increasingly effective treatments for this debilitating disease.

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