纳米疗法:即将问世的治疗癌症的纳米药物。

IF 3.7 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY IUBMB Life Pub Date : 2024-03-05 DOI:10.1002/iub.2814
Hamda Khan, Uzma Shahab, Ahmed Alshammari, Amjad R. Alyahyawi, Rihab Akasha, Talal Alharazi, Rizwan Ahmad, Afreen Khanam, Safia Habib, Kirtanjot Kaur, Saheem Ahmad,  Moinuddin
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引用次数: 0

摘要

纳米技术被认为是诊断和治疗癌症的成功方法。通过纳米给药系统进行癌细胞识别和药物靶向治疗的首选方法包括将抗癌药物渗透到细胞膜中,通过蛋白质修饰、DNA 氧化或线粒体功能障碍来破坏癌细胞。过去对纳米给药系统及其靶点的研究已经证明了其对恶性肿瘤的益处。以各种纳米载体为基础的多功能平台提供了利用创造性纳米材料治疗癌症的现代观念,该平台可同时进行成像和癌症治疗。新兴的癌症治疗纳米给药系统仍然缺乏对纳米粒子与癌细胞相互作用背后的生物功能的了解。由于工程纳米粒子的潜力可以解决各种挑战,从而限制了癌症治疗的成功,因此必须对纳米给药系统的分子靶向性进行审查,以提高对癌症的治疗效果。本综述重点介绍使用纳米给药系统、成像系统和封装纳米粒子进行癌症治疗。
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Nano-therapeutics: The upcoming nanomedicine to treat cancer

Nanotechnology is considered a successful approach for cancer diagnosis and treatment. Preferentially, cancer cell recognition and drug targeting via nano-delivery system include the penetration of anticancer agents into the cell membrane to damage the cancer cell by protein modification, DNA oxidation, or mitochondrial dysfunction. The past research on nano-delivery systems and their target has proven the beneficial achievement in a malignant tumor. Modern perceptions using inventive nanomaterials for cancer management have been offered by a multifunctional platform based on various nano-carriers with the probability of imaging and cancer therapy simultaneously. Emerging nano-delivery systems in cancer therapy still lack knowledge of the biological functions behind the interaction between nanoparticles and cancer cells. Since the potential of engineered nanoparticles addresses the various challenges, limiting the success of cancer therapy subsequently, it is a must to review the molecular targeting of a nano-delivery system to enhance the therapeutic efficacy of cancer. This review focuses on using a nano-delivery system, an imaging system, and encapsulated nanoparticles for cancer therapy.

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来源期刊
IUBMB Life
IUBMB Life 生物-生化与分子生物学
CiteScore
10.60
自引率
0.00%
发文量
109
审稿时长
4-8 weeks
期刊介绍: IUBMB Life is the flagship journal of the International Union of Biochemistry and Molecular Biology and is devoted to the rapid publication of the most novel and significant original research articles, reviews, and hypotheses in the broadly defined fields of biochemistry, molecular biology, cell biology, and molecular medicine.
期刊最新文献
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