鲍曼尼氏菌 ATCC 17961 O 抗原的片段合成

IF 1.7 4区化学 Q3 CHEMISTRY, ORGANIC Synlett Pub Date : 2024-03-04 DOI:10.1055/a-2272-8163

Xinxin Li, Liangshen Duan, Deyong Liu, Jianying Qi, Liming Wang, Qingju Zhang

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引用次数: 0

摘要

鲍曼不动杆菌可引起多种疾病，包括败血症、肺炎、脑膜炎、软组织和尿路感染。在此，我们介绍了从鲍曼不动杆菌 ATCC 17961 O 抗原中提取的一种三糖和两种四糖片段的合成过程，这些片段可用于筛选新型糖表位和开发基于碳水化合物的合成疫苗来预防鲍曼不动杆菌感染。合成所需的三糖 1、四糖 2 和四糖 3 的总产率分别为 26.8%（8 步）、21.6%（9 步）和 24.5%（6 步）。

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Fragments Synthesis of A. baumannii ATCC 17961 O-Antigen

Acinetobacter baumannii can cause many diseases including septicemia, pneumonia, meningitis, soft tissue, and urinary tract infections. Herein, we described the synthesis of one trisaccharide and two tetrasaccharide fragments derived from A. baumannii ATCC 17961 O-antigen that can be used for screening novel glyco-epitopes and for developing a synthetic carbohydrate-based vaccine against A. baumannii infection. The overall yields for the synthesis of the desired trisaccharide 1, tetrasaccharide 2, and tetrasaccharide 3 are 26.8% (8 steps), 21.6% (9 steps), and 24.5% (6 steps), respectively.

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来源期刊

Synlett 化学-有机化学

CiteScore

3.40

自引率

5.00%

发文量

369

审稿时长

1 months

期刊介绍： SYNLETT is an international journal reporting research results and current trends in chemical synthesis in short personalized reviews and preliminary communications. It covers all fields of scientific endeavor that involve organic synthesis, including catalysis, organometallic, medicinal, biological, and photochemistry, but also related disciplines and offers the possibility to publish scientific primary data.