断奶后的社会隔离会以特定区域的方式改变青春期雄性大鼠与奖赏相关的多巴胺动态变化

IF 4.3 2区 医学 Q1 NEUROSCIENCES Neurobiology of Stress Pub Date : 2024-03-02 DOI:10.1016/j.ynstr.2024.100620
Valeria Lallai , Cristina Congiu , Giulia Craig , Letizia Manca , Yen-Chu Chen , Angeline J. Dukes , Christie D. Fowler , Laura Dazzi
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引用次数: 0

摘要

早期发育的特点是大脑成熟的动态过渡,这可能会受到环境因素的影响。在此,我们试图确定断奶后和青春期的社会隔离对雄性大鼠奖励行为和多巴胺能信号传导的影响。受试者在出生后第 21 天被隔离或集体饲养。三周后,在喂食过程中检测内侧前额叶皮层(mPFC)和伏隔核(NAc)的细胞外多巴胺浓度。令人惊讶的是,研究人员发现,分组饲养的大鼠(而非隔离饲养的大鼠)mPFC多巴胺浓度增加,而分组饲养的大鼠(而非隔离饲养的大鼠)则相反。与此形成鲜明对比的是,隔离饲养的大鼠多巴胺水平升高,而非分组饲养的大鼠多巴胺水平升高。此外,隔离大鼠的 mPFC 没有受到影响,但随后的分组饲养却无法逆转,这表明多巴胺信号动态受到了显著的长期影响。当提供一种高适口性食物时,当巧克力是一种新奇的食物时,隔离受试者表现出 mPFC 多巴胺水平的急剧上升,但长期食用巧克力后则没有任何影响。相比之下,群居受试者只有在长期食用巧克力时多巴胺水平才会显著增加。多巴胺的变化与行为测量的差异相关。重要的是,在多巴胺或可卡因显微注射到mPFC后,隔离期间奖赏相关行为的缺失可以逆转。总之,这些数据提供了证据,表明从断奶后到青春期的社会隔离会以特定脑区的方式改变奖赏诱导的多巴胺水平,这对奖赏相关行为具有重要的功能影响。
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Social isolation postweaning alters reward-related dopamine dynamics in a region-specific manner in adolescent male rats

Early development is characterized by dynamic transitions in brain maturation, which may be impacted by environmental factors. Here, we sought to determine the effects of social isolation from postweaning and during adolescence on reward behavior and dopaminergic signaling in male rats. Subjects were socially isolated or group housed at postnatal day 21. Three weeks later, extracellular dopamine concentrations were examined in the medial prefrontal cortex (mPFC) and nucleus accumbens shell (NAc) during a feeding bout. Surprisingly, opposing effects were found in which increased mPFC dopamine concentrations were observed in group housed, but not isolated, rats. In stark contrast, increased dopamine levels were found in the NAc of isolated, but not group housed, rats. Moreover, the absence of an effect in the mPFC of the isolated rats could not be reversed by subsequent group housing, demonstrating the remarkable long-term effects on dopamine signaling dynamics. When provided a highly palatable food, the isolated subjects exhibited a dramatic increase in mPFC dopamine levels when the chocolate was novel, but no effects following chronic chocolate consumption. In contrast, the group housed subjects showed significantly increased dopamine levels only with chronic chocolate consumption. The dopamine changes were correlated with differences in behavioral measures. Importantly, the deficit in reward-related behavior during isolation could be reversed by microinjection of either dopamine or cocaine into the mPFC. Together, these data provide evidence that social isolation from postweaning and during adolescence alters reward-induced dopamine levels in a brain region-specific manner, which has important functional implications for reward-related behavior.

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来源期刊
Neurobiology of Stress
Neurobiology of Stress Biochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
9.40
自引率
4.00%
发文量
74
审稿时长
48 days
期刊介绍: Neurobiology of Stress is a multidisciplinary journal for the publication of original research and review articles on basic, translational and clinical research into stress and related disorders. It will focus on the impact of stress on the brain from cellular to behavioral functions and stress-related neuropsychiatric disorders (such as depression, trauma and anxiety). The translation of basic research findings into real-world applications will be a key aim of the journal. Basic, translational and clinical research on the following topics as they relate to stress will be covered: Molecular substrates and cell signaling, Genetics and epigenetics, Stress circuitry, Structural and physiological plasticity, Developmental Aspects, Laboratory models of stress, Neuroinflammation and pathology, Memory and Cognition, Motivational Processes, Fear and Anxiety, Stress-related neuropsychiatric disorders (including depression, PTSD, substance abuse), Neuropsychopharmacology.
期刊最新文献
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