{"title":"[隐球菌脑膜炎伴有脑积水的免疫功能正常患者]。","authors":"Julián Castro Castro, María Dolores Díaz López","doi":"10.23938/ASSN.1067","DOIUrl":null,"url":null,"abstract":"<p><p>Cryptococcal meningitis is an infrequent infection with high morbidity and mortality. Its presentation in immunocompetent patients is rare. We present the case of a 67-year-old male who was admitted for subacute symptoms of gait disturbance and urinary incontinence. Neurological examination revealed inability to stand and memory impairment. Cranial imaging showed obstructive tetraventricular hydrocephalus with areas of gliosis in the cerebellar peduncles. Endoscopic treatment of hydrocephalus was performed and cerebrospinal fluid samples taken revealing the growth of Cryptococcus neoformans. The patient improved with the endoscopic treatment and after completing intravenous antifungal therapy with liposomal amphotericin B and fluconazole for ten weeks. Antifungals are used to treat cryptococcal meningitis in immunocompetent patients. On rare occasions, it presents with hydrocephalus, a situation that requires surgical treatment using cerebrospinal fluid diversions or endoscopic techniques.</p>","PeriodicalId":500996,"journal":{"name":"Anales del sistema sanitario de Navarra","volume":"47 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10933692/pdf/","citationCount":"0","resultStr":"{\"title\":\"[Cryptococcal meningitis associated with hydrocephalus in an immunocompetent patient].\",\"authors\":\"Julián Castro Castro, María Dolores Díaz López\",\"doi\":\"10.23938/ASSN.1067\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Cryptococcal meningitis is an infrequent infection with high morbidity and mortality. Its presentation in immunocompetent patients is rare. We present the case of a 67-year-old male who was admitted for subacute symptoms of gait disturbance and urinary incontinence. Neurological examination revealed inability to stand and memory impairment. Cranial imaging showed obstructive tetraventricular hydrocephalus with areas of gliosis in the cerebellar peduncles. Endoscopic treatment of hydrocephalus was performed and cerebrospinal fluid samples taken revealing the growth of Cryptococcus neoformans. The patient improved with the endoscopic treatment and after completing intravenous antifungal therapy with liposomal amphotericin B and fluconazole for ten weeks. Antifungals are used to treat cryptococcal meningitis in immunocompetent patients. On rare occasions, it presents with hydrocephalus, a situation that requires surgical treatment using cerebrospinal fluid diversions or endoscopic techniques.</p>\",\"PeriodicalId\":500996,\"journal\":{\"name\":\"Anales del sistema sanitario de Navarra\",\"volume\":\"47 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-03-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10933692/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Anales del sistema sanitario de Navarra\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.23938/ASSN.1067\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Anales del sistema sanitario de Navarra","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.23938/ASSN.1067","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
隐球菌脑膜炎是一种不常见的感染,发病率和死亡率都很高。在免疫功能正常的患者中发病十分罕见。我们介绍了一例 67 岁男性患者的病例,他因步态障碍和尿失禁的亚急性症状入院。神经系统检查显示他无法站立,记忆力受损。头颅造影显示梗阻性四室脑积水,小脑脚有神经胶质增生区域。对脑积水进行了内窥镜治疗,并采集了脑脊液样本,结果显示有新生隐球菌生长。经过内窥镜治疗,并使用两性霉素 B 脂质体和氟康唑进行为期十周的静脉抗真菌治疗后,患者病情有所好转。抗真菌药物可用于治疗免疫功能正常患者的隐球菌性脑膜炎。在极少数情况下,它会出现脑积水,这种情况需要使用脑脊液引流或内窥镜技术进行手术治疗。
[Cryptococcal meningitis associated with hydrocephalus in an immunocompetent patient].
Cryptococcal meningitis is an infrequent infection with high morbidity and mortality. Its presentation in immunocompetent patients is rare. We present the case of a 67-year-old male who was admitted for subacute symptoms of gait disturbance and urinary incontinence. Neurological examination revealed inability to stand and memory impairment. Cranial imaging showed obstructive tetraventricular hydrocephalus with areas of gliosis in the cerebellar peduncles. Endoscopic treatment of hydrocephalus was performed and cerebrospinal fluid samples taken revealing the growth of Cryptococcus neoformans. The patient improved with the endoscopic treatment and after completing intravenous antifungal therapy with liposomal amphotericin B and fluconazole for ten weeks. Antifungals are used to treat cryptococcal meningitis in immunocompetent patients. On rare occasions, it presents with hydrocephalus, a situation that requires surgical treatment using cerebrospinal fluid diversions or endoscopic techniques.