重症 COVID-19 肺炎患者在接受类固醇治疗后，因曲霉菌心内膜炎并发播散而接受药物治疗的长期存活率

IF 1.6 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Medical Mycology Case Reports Pub Date : 2024-03-01 DOI:10.1016/j.mmcr.2024.100638

Kiran G. Kulirankal , Ann Mary , Merlin Moni , Gopal S. Pillai , Dipu T. Sathyapalan

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引用次数: 0

摘要

一名 40 多岁的男性患者没有已知的合并症，却患上了严重的 COVID-19 肺炎，并接受了为期四周的甲基强的松龙治疗。患者随后发展为播散性曲霉菌心内膜炎，表现为心脏、眼睛和大脑等多器官受累。尽管真菌性心内膜炎的预后通常较差，但患者在接受了两性霉素 b 脂质体和伏立康唑联合治疗后，经过积极的药物治疗得以存活。

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Long-term survival following medical management of Aspergillus endocarditis with dissemination as a consequence of steroid therapy in severe COVID-19 pneumonia

A male in his 40's with no known comorbidities developed severe COVID-19 pneumonia and received a four-week course of methylprednisolone. The patient subsequently developed disseminated Aspergillus endocarditis, manifesting as multiple organ involvement including the heart, eyes, and brain. Despite the poor prognosis generally associated with fungal endocarditis, the patient survived following aggressive medical management with a combination of liposomal amphotericin b and voriconazole therapy and is now doing well for over two years and is off antifungal therapy for a year.

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