南亚小儿急性肾损伤评估:评估南亚小儿急性肾损伤:流行病学和风险因素 (ASPIRE)--一项关于 "严重透析依赖性小儿急性肾损伤 "的前瞻性研究。

IF 2.6 3区 医学 Q1 PEDIATRICS Pediatric Nephrology Pub Date : 2024-12-01 Epub Date: 2024-03-08 DOI:10.1007/s00467-024-06324-6
Sidharth Kumar Sethi, Rupesh Raina, Ahmad Sawan, Sadaf Asim, Aye Kyawt Khant, Manoj Matnani, Kalaivani Ganesan, Shraddha Lohia, Rajiv Sinha, Jubaida Rumana, Syed Saimul Haque, Suprita Kalra, Rabia Safdar, Gopal Prasad, Iftikhar Ijaz, Omer S Ashruf, Aishwarya Nair, Savita S, Kritika Soni, Devendra Shrestha, Shankar Yadav, Asiri Abeyagunawardena, Valerie A Luyckx, Khalid A Alhasan, Azmeri Sultana
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引用次数: 0

摘要

背景:小儿急性肾损伤(AKI)是一个全球关注的健康问题,在资源有限的环境中,相关的死亡风险尤为突出。了解弱势人群中小儿急性肾损伤的流行病学亟待解决。在此,我们提议开展一项前瞻性研究,调查南亚国家儿童 "严重透析依赖性 AKI "的流行病学和相关风险因素,这将是同类研究中首个也是最大的一个:ASPIRE 研究(PCRRT-ICONIC 基金会倡议的一部分)是一项在南亚国家开展的多中心前瞻性观察研究。所有在合作医疗中心接受透析治疗的 18 岁以下儿童和青少年均被纳入研究。数据收集工作一直持续到观察到下列终点之一为止:(1)出院,(2)死亡,(3)违反医嘱出院:从2019年到2022年,共有308名严重AKI患儿入组。平均年龄为 6.17 岁(男性占 63%)。继发性 AKI 的发病率高于原发性 AKI(67.2%),其主要原因是感染、脱水和肾毒素。原发性 AKI 的常见病因是肾小球肾炎、溶血性尿毒症综合征、狼疮性肾炎和梗阻性尿病。需要透析的严重缺氧性肾损伤患儿通常会出现休克、需要通气和凝血功能障碍。最常用的肾脏替代疗法是腹膜透析(60.7%)。死亡率为 32.1%:结论:南亚儿童 AKI 的常见病因是可以预防的。结论:南亚儿童急性缺氧性心肌梗死的常见病因是可以预防的,但患有 "严重透析依赖性急性缺氧性心肌梗死 "的儿童死亡率很高。在资源匮乏的国家,需要采取有针对性的干预措施,及早预防和识别 AKI,并启动支持性护理。
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RETRACTED ARTICLE: Assessment of South Asian Pediatric Acute Kidney Injury: Epidemiology and Risk Factors (ASPIRE)-a prospective study on "severe dialysis dependent pediatric AKI".
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来源期刊
Pediatric Nephrology
Pediatric Nephrology 医学-泌尿学与肾脏学
CiteScore
4.70
自引率
20.00%
发文量
465
审稿时长
1 months
期刊介绍: International Pediatric Nephrology Association Pediatric Nephrology publishes original clinical research related to acute and chronic diseases that affect renal function, blood pressure, and fluid and electrolyte disorders in children. Studies may involve medical, surgical, nutritional, physiologic, biochemical, genetic, pathologic or immunologic aspects of disease, imaging techniques or consequences of acute or chronic kidney disease. There are 12 issues per year that contain Editorial Commentaries, Reviews, Educational Reviews, Original Articles, Brief Reports, Rapid Communications, Clinical Quizzes, and Letters to the Editors.
期刊最新文献
Concurrent use of continuous kidney replacement therapy during extracorporeal membrane oxygenation: what pediatric nephrologists need to know-PCRRT-ICONIC practice points. Furosemide stress test to predict acute kidney injury progression in critically ill children. A better future for children with STEC-hemolytic uremic syndrome: news from Argentina. Acetaminophen induced high anion gap metabolic acidosis: a potentially under-recognized consequence from a common medication. Malnutrition management in children with chronic kidney disease.
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