奥马珠单抗治疗一名少女的莫尔比昂综合征--病例报告和文献综述。

IF 2.5 4区 医学 Q3 ALLERGY Allergologia et immunopathologia Pub Date : 2024-03-01 eCollection Date: 2024-01-01 DOI:10.15586/aei.v52i2.978
Zofia Mazurek-Durlak, Katarzyna Mularczyk, Przemko Kwinta, Grzegorz Lis, Ewa Cichocka-Jarosz
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引用次数: 0

摘要

莫尔比昂综合征(Morbihan syndrome,MS)的特征是面部实性水肿,通常与酒渣鼻或寻常痤疮有关。面部水肿会使患者的五官变形,损害周边视力,影响生活质量。其病理生理学尚不清楚。该病的病程通常缓慢而慢性。多发性硬化症最常见于患有酒糟鼻的中年白种男性,20 岁以下的人很少发病。多发性硬化症是一种排除性诊断。目前还没有治疗多发性硬化症的标准方法,但主要使用全身性异维A酸和抗组胺药。我们介绍了一个患有多发性硬化症的少女病例,她在接受了 19 个月的异维A酸治疗后,对抗组胺药物无反应。每月使用奥马珠单抗(抗 IgE)治疗 6 个月是一种有效的治疗方案,可改善患者的生活质量。我们的病例是第二例使用奥马珠单抗治疗莫尔比昂综合征的病例,第一例是一名青少年。
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Omalizumab in the treatment of Morbihan syndrome in an adolescent girl - case report and literature review.

Morbihan syndrome (MS) is characterized by solid facial edema, usually related to rosacea or acne vulgaris. The facial edema deforms the patient's features, can impair peripheral vision, and affects quality of life. Its pathophysiology remains unclear. The disease usually has a slow and chronic course. MS most commonly affects middle-aged Caucasian men with rosacea and is rare in people below 20 years of age. MS is a diagnosis of exclusion. There is no standard treatment for MS, though systemic isotretinoin and antihistamines are mainly used. We present the case of an adolescent girl with MS nonresponding to 19 months of isotretinoin treatment with add-on antihistamines. Therapy with monthly administration of omalizumab (anti-IgE) for 6 months was an effective therapeutic option, improving the quality of life. Our case is the second description of omalizumab use in Morbihan syndrome, the first in an adolescent.

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来源期刊
CiteScore
3.70
自引率
0.00%
发文量
131
审稿时长
6-12 weeks
期刊介绍: Founded in 1972 by Professor A. Oehling, Allergologia et Immunopathologia is a forum for those working in the field of pediatric asthma, allergy and immunology. Manuscripts related to clinical, epidemiological and experimental allergy and immunopathology related to childhood will be considered for publication. Allergologia et Immunopathologia is the official journal of the Spanish Society of Pediatric Allergy and Clinical Immunology (SEICAP) and also of the Latin American Society of Immunodeficiencies (LASID). It has and independent international Editorial Committee which submits received papers for peer-reviewing by international experts. The journal accepts original and review articles from all over the world, together with consensus statements from the aforementioned societies. Occasionally, the opinion of an expert on a burning topic is published in the "Point of View" section. Letters to the Editor on previously published papers are welcomed. Allergologia et Immunopathologia publishes 6 issues per year and is included in the major databases such as Pubmed, Scopus, Web of Knowledge, etc.
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