深入了解儿茶素的治疗潜力、药物配方、化学和分析方法

IF 7.3 2区 生物学 Q1 PLANT SCIENCES Phytochemistry Reviews Pub Date : 2024-03-11 DOI:10.1007/s11101-024-09929-9
Divya Shikha, Amandeep Singh, Naresh Kumar Rangra, Vikramdeep Monga, Rohit Bhatia
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引用次数: 0

摘要

儿茶素是从大自然的神圣财富中获得的著名植物成分之一。儿茶素是一种多酚成分,广泛分布于植物界,茶叶、豆科植物和芸香科植物都是儿茶素的丰富来源。由于儿茶素具有多种药理作用,不同的研究小组通过不同的分析技术提取和分离了儿茶素。儿茶素具有抗炎、保护神经、抗氧化、抗菌、抗癌和抗病毒的功效。据报道,有几种用于多种用途的配方都以儿茶素为重要成分。这篇综述讨论了从各种来源中提取和分离儿茶素所采用的各种分析技术,并概述了所报道的各种配方。作者还讨论了儿茶素表现出的各种药理活性,以及重要的结果和合理的作用模式。此外,这篇综述还深入探讨了儿茶素的各种合成和生物合成过程,并介绍了各种临床试验和专利。本汇编的横向部分深入介绍了儿茶素的各种合成/生物合成程序,以及各种临床试验和专利。虽然在儿茶素的开发方面取得了很大进展,但仍存在一些生物利用率和作用模式不明确的问题,需要在今后的时间里加以解决。这篇综述对儿茶素的研究更为全面,因为它涵盖了更广泛的主题,包括儿茶素提取和分离的分析技术、含有儿茶素的配方、药理活性、合成和生物合成过程、临床试验以及专利。该综述还对儿茶素的药理活性进行了更深入的讨论,包括重要结果和可信的作用模式。文章还强调了进一步研究的必要性,以解决生物利用率和儿茶素相关作用模式不明确的问题。这是一个重要的研究领域,因为了解 ADME 对开发基于儿茶素的有效疗法至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Insights to therapeutic potentials, pharmaceutical formulations, chemistry and analytical methods of catechin

Catechin is one of the prestigious phytoconstituent obtained from the divine wealth of nature. It is a polyphenolic constituent which is broadly distributed in plant kingdom and tea, legumes and rubeaceous plants are rich sources of it. Various research groups have extracted and isolated it by using different analytical techniques due to its diverse pharmacological profile. It is evident in nature that catechin possesses promising anti-inflammatory, neuroprotective, antioxidant, antibacterial, anticancer and anti-viral properties. There are several formulations reported which are intended for multiple uses where catechins are important ingredient. This review discusses the various analytical techniques employed for the extraction and isolation of catechins from various sources, as well as a summary of various reported formulations. The authors also discuss the various pharmacological activities exhibited by catechins, along with the significant outcomes and plausible mode of action. In addition, the review provides an insight into various synthetic and biosynthetic procedures for catechins, along with a description of various clinical trials and patents. In the lateral sections of this compilation, an insight to various synthetic/biosynthetic procedures for catechins has been provided along with description to various clinical trials and patents. Although a lot of progress has been made towards exploration of catechins, still these are associated with some issues of bioavailability and unclear modes of action, which need to be resolved in upcoming times. This review is more comprehensive on catechins, as it covers a wider range of topic includings; analytical techniques for the extraction and isolations of catechins, formulations containing catechins, pharmacological activities, synthetic and biosynthetic procedure, clinical trials as well as patents. The review also provide a more in-depth discussion of the pharmacological activities of catechins, including the significant outcomes and plausible mode of action. The article also highlights the need for the further research to address the issues of bioavailability and unclear modes of action associated with the catechin. This is an important area of research, as it is essential to understand the ADME to develop effective catechin-based therapies.

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来源期刊
Phytochemistry Reviews
Phytochemistry Reviews PLANT SCIENCES-
CiteScore
16.30
自引率
2.60%
发文量
54
审稿时长
2 months
期刊介绍: Phytochemistry Reviews is the sole review journal encompassing all facets of phytochemistry. It publishes peer-reviewed papers in six issues annually, including topical issues often stemming from meetings organized by the Phytochemical Society of Europe. Additionally, the journal welcomes original review papers that contribute to advancing knowledge in various aspects of plant chemistry, function, biosynthesis, effects on plant and animal physiology, pathology, and their application in agriculture and industry. Invited meeting papers are supplemented with additional review papers, providing a comprehensive overview of the current status across all areas of phytochemistry.
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