间充质干细胞在定向微结构薄膜和电纺支架上的生长

Q3 Agricultural and Biological Sciences Moscow University Biological Sciences Bulletin Pub Date : 2024-03-11 DOI:10.3103/s0096392523700189

I. V. Demianova, E. A. Akoulina, I. I. Zharkova, V. V. Voinova, D. V. Chesnokova, A. M. Hossain, T. K. Makhina, G. A. Bonartseva, V. I. Kulikouskaya, V. V. Nikalaichuk, Yu. R. Mukhortova, A. S. Pryadko, M. A. Surmeneva, R. A. Surmenev, K. V. Shaitan, A. P. Bonartsev

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引用次数: 0

摘要

摘要该研究采用各种方法制造了不同粗糙度的薄膜和聚-3-羟基丁酸酯支架。根据聚合物浓度和电纺丝参数的不同，通过电纺丝方法获得了纤维粗细不同的混沌和定向支架。利用旋涂和自组装方法获得了不同表面粗糙度的薄膜。实验证明，不同的表面微结构不会影响间充质干细胞在一周内的生长，但会影响粘附细胞的形态。

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Growth of Mesenchymal Stem Cells on Oriented Microstructured Films and Electrospun Scaffolds

Abstract

The study involved the fabrication of films with different roughness and scaffolds made of poly-3-hydroxybutyrate using various methods. Chaotic and oriented scaffolds with varying fiber thickness were obtained through the electrospinning method, depending on the polymer concentration and electrospinning parameters. Films with different surface roughness were obtained using spin coating and self-assembly methods. It was demonstrated that the varying microstructure of the surface does not affect the growth of mesenchymal stem cells over the course of 1 week; however, it does influence the morphology of the adhered cells.

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来源期刊

Moscow University Biological Sciences Bulletin Agricultural and Biological Sciences-Agricultural and Biological Sciences (all)

CiteScore

1.00

自引率

0.00%

发文量

期刊介绍： Moscow University Biological Sciences Bulletin is forum for research in all important areas of modern biology. It publishes original work on qualitative, analytical and experimental aspects of research. The scope of articles to be considered includes plant biology, zoology, ecology, evolutionary biology, biophysics, genetics, genomics, proteomics, molecular biology, cell biology, biochemistry, endocrinology, immunology, physiology, pharmacology, neuroscience, gerontology, developmental biology, bioinformatics, bioengineering, virology, and microbiology.