临床前癌症研究中的正位和转移性肿瘤模型。

IF 12 1区 医学 Q1 PHARMACOLOGY & PHARMACY Pharmacology & Therapeutics Pub Date : 2024-03-11 DOI:10.1016/j.pharmthera.2024.108631
Stephen M. Stribbling , Callum Beach , Anderson J. Ryan
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引用次数: 0

摘要

小鼠疾病模型在癌症药物开发的各个阶段都起着举足轻重的作用。细胞系衍生的皮下肿瘤模型在早期药物发现中占主导地位,但越来越多的人认识到更复杂的原位和转移肿瘤模型对于了解正确组织背景下的靶点生物学以及肿瘤微环境和免疫系统对治疗反应的影响的重要性。本综述旨在强调原位和转移瘤模型对肿瘤生物学研究和药物开发的价值,同时指出文献中最有可能出现的模型。本文讨论了正位模型的重要发展,如越来越多地使用早期病人材料(PDXs、organoids)和人源化小鼠模型,因为这些方法有可能提高临床前研究的预测价值,并最终提高抗癌药物在临床试验中的成功率。
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Orthotopic and metastatic tumour models in preclinical cancer research

Mouse models of disease play a pivotal role at all stages of cancer drug development. Cell-line derived subcutaneous tumour models are predominant in early drug discovery, but there is growing recognition of the importance of the more complex orthotopic and metastatic tumour models for understanding both target biology in the correct tissue context, and the impact of the tumour microenvironment and the immune system in responses to treatment. The aim of this review is to highlight the value that orthotopic and metastatic models bring to the study of tumour biology and drug development while pointing out those models that are most likely to be encountered in the literature. Important developments in orthotopic models, such as the increasing use of early passage patient material (PDXs, organoids) and humanised mouse models are discussed, as these approaches have the potential to increase the predictive value of preclinical studies, and ultimately improve the success rate of anticancer drugs in clinical trials.

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来源期刊
CiteScore
23.00
自引率
0.70%
发文量
222
审稿时长
90 days
期刊介绍: Pharmacology & Therapeutics, in its 20th year, delivers lucid, critical, and authoritative reviews on current pharmacological topics.Articles, commissioned by the editor, follow specific author instructions.This journal maintains its scientific excellence and ranks among the top 10 most cited journals in pharmacology.
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