{"title":"基于世卫组织 2021 年新分类的[11C]蛋氨酸 PET 与贝叶斯惩罚似然重建对胶质瘤分级的影响。","authors":"Kei Wagatsuma, Kensuke Ikemoto, Motoki Inaji, Yuto Kamitaka, Shoko Hara, Kaoru Tamura, Kenta Miwa, Kaede Tsuzura, Taisei Tsuruki, Noriaki Miyaji, Kenji Ishibashi, Kenji Ishii","doi":"10.1007/s12149-024-01911-x","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>The uptake of [<sup>11</sup>C]methionine in positron emission tomography (PET) imaging overlapped in earlier images of tumors. Bayesian penalized likelihood (BPL) reconstruction increases the quantitative values of tumors compared with conventional ordered subset-expectation maximization (OSEM). The present study aimed to grade glioma malignancy based on the new WHO 2021 classification using [<sup>11</sup>C]methionine PET images reconstructed using BPL.</p><h3>Methods</h3><p>We categorized 32 gliomas in 28 patients as grades 2/3 (<i>n</i> = 15) and 4 (<i>n</i> = 17) based on the WHO 2021 classification. All [<sup>11</sup>C]methionine images were reconstructed using OSEM + time-of-flight (TOF) and BPL + TOF (<i>β = </i>200). Maximum standardized uptake value (SUV<sub>max</sub>) and tumor-to-normal tissue ratio (T/N<sub>max</sub>) were measured at each lesion.</p><h3>Results</h3><p>The mean SUV<sub>max</sub> was 4.65 and 4.93 in grade 2/3 and 6.38 and 7.11 in grade 4, and the mean T/N<sub>max</sub> was 7.08 and 7.22 in grade 2/3 and 9.30 and 10.19 in grade 4 for OSEM and BPL, respectively. The BPL significantly increased these values in grade 4 gliomas. The area under the receiver operator characteristic (ROC) curve (AUC) for SUV<sub>max</sub> was the highest (0.792) using BPL.</p><h3>Conclusions</h3><p>The BPL increased mean SUV<sub>max</sub> and mean T/N<sub>max</sub> in lesions with higher contrast such as grade 4 glioma. The discrimination power between grades 2/3 and 4 in SUV<sub>max</sub> was also increased using [<sup>11</sup>C]methionine PET images reconstructed with BPL.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"38 5","pages":"400 - 407"},"PeriodicalIF":2.5000,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Impact of [11C]methionine PET with Bayesian penalized likelihood reconstruction on glioma grades based on new WHO 2021 classification\",\"authors\":\"Kei Wagatsuma, Kensuke Ikemoto, Motoki Inaji, Yuto Kamitaka, Shoko Hara, Kaoru Tamura, Kenta Miwa, Kaede Tsuzura, Taisei Tsuruki, Noriaki Miyaji, Kenji Ishibashi, Kenji Ishii\",\"doi\":\"10.1007/s12149-024-01911-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>The uptake of [<sup>11</sup>C]methionine in positron emission tomography (PET) imaging overlapped in earlier images of tumors. Bayesian penalized likelihood (BPL) reconstruction increases the quantitative values of tumors compared with conventional ordered subset-expectation maximization (OSEM). The present study aimed to grade glioma malignancy based on the new WHO 2021 classification using [<sup>11</sup>C]methionine PET images reconstructed using BPL.</p><h3>Methods</h3><p>We categorized 32 gliomas in 28 patients as grades 2/3 (<i>n</i> = 15) and 4 (<i>n</i> = 17) based on the WHO 2021 classification. All [<sup>11</sup>C]methionine images were reconstructed using OSEM + time-of-flight (TOF) and BPL + TOF (<i>β = </i>200). Maximum standardized uptake value (SUV<sub>max</sub>) and tumor-to-normal tissue ratio (T/N<sub>max</sub>) were measured at each lesion.</p><h3>Results</h3><p>The mean SUV<sub>max</sub> was 4.65 and 4.93 in grade 2/3 and 6.38 and 7.11 in grade 4, and the mean T/N<sub>max</sub> was 7.08 and 7.22 in grade 2/3 and 9.30 and 10.19 in grade 4 for OSEM and BPL, respectively. The BPL significantly increased these values in grade 4 gliomas. The area under the receiver operator characteristic (ROC) curve (AUC) for SUV<sub>max</sub> was the highest (0.792) using BPL.</p><h3>Conclusions</h3><p>The BPL increased mean SUV<sub>max</sub> and mean T/N<sub>max</sub> in lesions with higher contrast such as grade 4 glioma. The discrimination power between grades 2/3 and 4 in SUV<sub>max</sub> was also increased using [<sup>11</sup>C]methionine PET images reconstructed with BPL.</p></div>\",\"PeriodicalId\":8007,\"journal\":{\"name\":\"Annals of Nuclear Medicine\",\"volume\":\"38 5\",\"pages\":\"400 - 407\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-03-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of Nuclear Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s12149-024-01911-x\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Nuclear Medicine","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s12149-024-01911-x","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0
摘要
目的：正电子发射断层扫描（PET）成像中[11C]蛋氨酸的摄取与肿瘤早期图像重叠。与传统的有序子集期望最大化（OSEM）相比，贝叶斯惩罚似然（BPL）重建提高了肿瘤的定量值。本研究旨在使用贝叶斯似然法重建的[11C]蛋氨酸 PET 图像，根据新的 WHO 2021 分类对胶质瘤的恶性程度进行分级：方法：根据WHO 2021分类法，我们将28名患者的32个胶质瘤分为2/3级（15人）和4级（17人）。所有[11C]蛋氨酸图像均采用 OSEM + 飞行时间 (TOF) 和 BPL + TOF（β = 200）重建。测量每个病灶的最大标准化摄取值（SUVmax）和肿瘤与正常组织比值（T/Nmax）：OSEM和BPL的平均SUVmax在2/3级分别为4.65和4.93，在4级分别为6.38和7.11；平均T/Nmax在2/3级分别为7.08和7.22，在4级分别为9.30和10.19。在 4 级胶质瘤中，BPL 能明显提高这些数值。BPL的SUVmax接收者操作特征曲线下面积（AUC）最高（0.792）：结论：BPL提高了4级胶质瘤等对比度较高病灶的平均SUVmax和平均T/Nmax。使用BPL重建的[11C]蛋氨酸PET图像还提高了SUVmax在2/3级和4级之间的分辨能力。
Impact of [11C]methionine PET with Bayesian penalized likelihood reconstruction on glioma grades based on new WHO 2021 classification
Objective
The uptake of [11C]methionine in positron emission tomography (PET) imaging overlapped in earlier images of tumors. Bayesian penalized likelihood (BPL) reconstruction increases the quantitative values of tumors compared with conventional ordered subset-expectation maximization (OSEM). The present study aimed to grade glioma malignancy based on the new WHO 2021 classification using [11C]methionine PET images reconstructed using BPL.
Methods
We categorized 32 gliomas in 28 patients as grades 2/3 (n = 15) and 4 (n = 17) based on the WHO 2021 classification. All [11C]methionine images were reconstructed using OSEM + time-of-flight (TOF) and BPL + TOF (β = 200). Maximum standardized uptake value (SUVmax) and tumor-to-normal tissue ratio (T/Nmax) were measured at each lesion.
Results
The mean SUVmax was 4.65 and 4.93 in grade 2/3 and 6.38 and 7.11 in grade 4, and the mean T/Nmax was 7.08 and 7.22 in grade 2/3 and 9.30 and 10.19 in grade 4 for OSEM and BPL, respectively. The BPL significantly increased these values in grade 4 gliomas. The area under the receiver operator characteristic (ROC) curve (AUC) for SUVmax was the highest (0.792) using BPL.
Conclusions
The BPL increased mean SUVmax and mean T/Nmax in lesions with higher contrast such as grade 4 glioma. The discrimination power between grades 2/3 and 4 in SUVmax was also increased using [11C]methionine PET images reconstructed with BPL.
期刊介绍：
Annals of Nuclear Medicine is an official journal of the Japanese Society of Nuclear Medicine. It develops the appropriate application of radioactive substances and stable nuclides in the field of medicine.
The journal promotes the exchange of ideas and information and research in nuclear medicine and includes the medical application of radionuclides and related subjects. It presents original articles, short communications, reviews and letters to the editor.
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