Jussi Tennilä, Harri Sintonen, Paulina Utriainen, Raimo Voutilainen, Jarmo Jääskeläinen, Jani Liimatta
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引用次数: 0
摘要
简介与同龄人相比，肾上腺早发育（PA）儿童的肾上腺雄激素浓度更高，青春期发育更早。性早熟和接触雄激素都与成年后神经心理逆境风险增加有关。这种逆境可能会影响受影响者的健康相关生活质量（HRQoL）：一项纵向病例对照队列研究，对 30 名 PA 女孩和 40 名年龄匹配的对照者进行了从童年到青年时期的跟踪调查。主要结果是 15D HRQoL 总分。此外，我们还对问卷的特定维度、受试者的关系状况和生活安排进行了评估：15D 总分（PA，0.956 (0.052)；对照组，0.947 (0.055)；P 0.482）或该工具的任何维度在组间均无差异：研究表明，有 PA 史不会导致成年后的 HRQoL 受损。
Health-related quality of life of young adult women with a history of premature adrenarche.
Introduction: Children with premature adrenarche (PA) have increased adrenal androgen concentrations and earlier pubertal development than their peers. Early sexual maturation and exposure to androgens have both been associated with an increased risk for neuropsychological adversities in adulthood. Such adversities would presumably influence the experienced health-related quality of life (HRQoL) of those affected.
Methods: A longitudinal case-control cohort study, in which 30 PA girls and 40 age-matched controls were followed from childhood to young adult age. The main outcome measure was the total 15D HRQoL score. In addition, we assessed specific dimensions of the questionnaire, the subjects' relationship statuses and living arrangements.
Results: There were no differences between the groups in the overall 15D scores (PA, 0.956 (0.052); control, 0.947 (0.055); p 0.482), or on any dimension of this instrument.
Conclusion: The study suggests that a history of PA does not lead to impaired HRQoL in adult age.
期刊介绍：
The mission of ''Hormone Research in Paediatrics'' is to improve the care of children with endocrine disorders by promoting basic and clinical knowledge. The journal facilitates the dissemination of information through original papers, mini reviews, clinical guidelines and papers on novel insights from clinical practice. Periodic editorials from outstanding paediatric endocrinologists address the main published novelties by critically reviewing the major strengths and weaknesses of the studies.
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