HIV 血清阳性和阴性人群饮酒与血压水平之间的关系：武库扎齐研究的二次分析。

IF 3 Q1 PRIMARY HEALTH CARE Journal of Primary Care and Community Health Pub Date : 2024-01-01 DOI:10.1177/21501319241235594

Manasseh B Wireko, Jacobus Hendricks, Kweku Bedu-Addo, Marlise Van Staden, Emmanuel A Ntim, John A Larbi, Isaac K Owusu

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A linear regression model was used to establish relationships among participants with raised blood pressure (BP ≥ 140/90 mmHg).Results: Out of the total participants, 3553 (19.82%) were hypertensives. Almost 13% of the hypertensives (n = 458; 12.89%) were undiagnosed, and 12.44 % (442) had uncontrolled hypertension. About 14.52% of the hypertensives (3553) were not on any antihypertensive medication. Male non-consumers of alcohol had the highest systolic and diastolic BP; uncontrolled systolic BP (165.53 ± 20.87 mmHg), uncontrolled diastolic BP (102.28 ± 19.21mmHg). Adjusted for covariates, moderate alcohol consumption was associated with HTN among participants who were HIV seropositive [unadjusted (RR = 1.772, P = .006, 95% CI (1.178-2.665)], [RR = 1.772, P = .005, 95% CI (1.187-2.64)]. [unadjusted RR = 1.876, P = .036, 95% CI (1.043-3.378)], adjusted RR = 1.876, P = .041, 95% CI (1.024-3.437). 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引用次数: 0

摘要

背景：饮酒等生活方式因素会加重高血压的影响。本研究旨在确定 HIV 血清阴性和血清阳性人群中饮酒与血压水平之间的关联：这项二次分析是对 2018 年至 2020 年期间 17 922 名参与者的横断面调查数据进行的。调查问卷用于获取参与者的饮酒史，并将其分为非饮酒者、非重度饮酒者和重度饮酒者。采用线性回归模型确定参与者与血压升高（血压≥ 140/90 mmHg）之间的关系：在所有参与者中，有 3553 人（19.82%）是高血压患者。近 13% 的高血压患者（n = 458；12.89%）未经诊断，12.44%（442 人）的高血压未得到控制。约 14.52% 的高血压患者（3553 人）没有服用任何降压药物。不饮酒的男性收缩压和舒张压最高；未控制的收缩压为（165.53 ± 20.87 mmHg），未控制的舒张压为（102.28 ± 19.21 mmHg）。经协变量调整后，在艾滋病毒血清反应呈阳性的参与者中，中度饮酒与高血压相关[未经调整（RR = 1.772，P = .006，95% CI (1.178-2.665)]，[RR = 1.772，P = .005，95% CI (1.187-2.64)]。[未调整 RR = 1.876，P = .036，95% CI (1.043-3.378)]，调整 RR = 1.876，P = .041，95% CI (1.024-3.437)。在艾滋病毒血清阴性者中，中度和重度饮酒均与高血压明显相关[未调整模型，中度饮酒 RR = 1.534，P = .003，95% CI (1.152-2.044)]，[调整模型，中度饮酒 RR = 1.535，P = .006，95% CI (1.132-2.080)]，[未调整模型，大量饮酒，RR = 2.480，P = .030，95% CI (1.091-5.638)]，[调整模型 RR = 2.480，P = .034，95% CI (1.072-5.738)]：结论：无论是否感染艾滋病毒，饮酒都与血压升高密切相关。

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Association Between Alcohol Consumption and Blood Pressure Levels Among HIV Sero-Positive and Sero-Negative Cohorts: A Secondary Analysis of the Vukuzazzi Study.

Background: The effect of hypertension is aggravated by lifestyle factors such as alcohol consumption. This study sought to determine the association between alcohol consumption and the level of blood pressures among HIV seronegative and seropositive cohorts.

Methods: This secondary analysis was performed on a cross-sectional survey data of 17 922 participants during the period between 2018 and 2020. A questionnaire was used to obtain participants' alcohol consumption history, which was categorized into non-alcohol consumers, non-heavy alcohol consumers, and heavy alcohol consumers. A linear regression model was used to establish relationships among participants with raised blood pressure (BP ≥ 140/90 mmHg).

Results: Out of the total participants, 3553 (19.82%) were hypertensives. Almost 13% of the hypertensives (n = 458; 12.89%) were undiagnosed, and 12.44 % (442) had uncontrolled hypertension. About 14.52% of the hypertensives (3553) were not on any antihypertensive medication. Male non-consumers of alcohol had the highest systolic and diastolic BP; uncontrolled systolic BP (165.53 ± 20.87 mmHg), uncontrolled diastolic BP (102.28 ± 19.21mmHg). Adjusted for covariates, moderate alcohol consumption was associated with HTN among participants who were HIV seropositive [unadjusted (RR = 1.772, P = .006, 95% CI (1.178-2.665)], [RR = 1.772, P = .005, 95% CI (1.187-2.64)]. [unadjusted RR = 1.876, P = .036, 95% CI (1.043-3.378)], adjusted RR = 1.876, P = .041, 95% CI (1.024-3.437). Both moderate and heavy alcohol consumption were significantly related to hypertension among HIV sero-negative [unadjusted model, moderate consumption RR = 1.534 P = .003, 95% CI (1.152-2.044)], [adjusted model, moderate alcohol consumption RR = 1.535, P = .006, 95% CI (1.132-2.080)], [unadjusted model, heavy alcohol consumption, RR = 2.480, P = .030, 95% CI (1.091-5.638)], [adjusted model RR = 2.480, P = .034, 95% CI (1.072-5.738)].

Conclusion: Alcohol consumption is significantly related to increase BP regardless of HIV infection.

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