姬松茸粗多糖的体外和体内抗高血糖作用

IF 1.4 4区 生物学 Q4 MYCOLOGY International journal of medicinal mushrooms Pub Date : 2024-03-01 DOI:10.1615/intjmedmushrooms.2024053173
Jinxiu Zhang, Lichao Guo, Qingguo Yao, Jianhua Lv, Zhuang Li, Li-an Wang
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引用次数: 0

摘要

全球糖尿病发病率不断上升,研究新的降血糖活性物质非常重要。在本研究中,我们研究了芦竹粗多糖(CRCP)在 HepG2 细胞和链脲佐菌素诱导的糖尿病小鼠中的降血糖作用。在 HepG2 细胞中进行的葡萄糖消耗实验证明了 CRCP 的体外降血糖活性。此外,CRCP 还具有明显的降血糖作用,并能有效改善胰岛素抵抗的 HepG2 细胞的胰岛素抵抗。在高脂饮食和链脲佐菌素诱导的糖尿病小鼠中,服用 CRCP 4 周后,空腹血糖、空腹血清胰岛素、甘油三酯、总胆固醇、低密度脂蛋白胆固醇、谷氨酸转氨酶、丙氨酸转氨酶和胰岛素抵抗指数显著下降,而高密度脂蛋白胆固醇和胰岛素敏感性指数(ISI)明显上升。此外,组织切片的苏木精-伊红(HE)染色和免疫荧光标记表明,CRCP减轻了糖尿病小鼠肝脏和胰腺的病理损伤。这些结果表明,CRCP 是一种潜在的降血糖药物。
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Anti-Hyperglycemic Effect of Mushroom Chroogomphus rutilus (Agaricomycetes) Crude Polysaccharide In Vitro and In Vivo
The prevalence of diabetes is increasing worldwide, and it is very important to study new hypoglycemic active substances. In this study, we investigated the hypoglycemic effect of Chroogomphus rutilus crude polysaccharide (CRCP) in HepG2 cells and streptozotocin-induced diabetic mice. A glucose consumption experiment conducted in HepG2 cells demonstrated the in vitro hypoglycemic activity of CRCP. Furthermore, CRCP exhibited significant hypoglycemic effects and effectively ameliorated insulin resistance in insulin resistant HepG2 cells. In high-fat diet and streptozotocin-induced diabetic mice, after 4 weeks of CRCP administration, fasting blood glucose, fasting serum insulin, triglyceride, total cholesterol, low-density lipoprotein cholesterol, glutamate transaminase, alanine transaminase, and insulin resistance index significantly decreased, while high-density lipoprotein cholesterol and insulin sensitivity index (ISI) were markedly increased. Moreover, hematoxylin-eosin (HE) staining and immunofluorescence labeling of tissue sections indicated that CRCP attenuated the pathological damage of liver and pancreas in diabetic mice. These results indicate that CRCP is a potential hypoglycemic agent.
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来源期刊
CiteScore
2.60
自引率
16.70%
发文量
91
审稿时长
6-12 weeks
期刊介绍: The rapid growth of interest in medicinal mushrooms research is matched by the large number of disparate groups that currently publish in a wide range of publications. The International Journal of Medicinal Mushrooms is the one source of information that will draw together all aspects of this exciting and expanding field - a source that will keep you up to date with the latest issues and practice. The International Journal of Medicinal Mushrooms published original research articles and critical reviews on a broad range of subjects pertaining to medicinal mushrooms, including systematics, nomenclature, taxonomy, morphology, medicinal value, biotechnology, and much more.
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