局部使用西多福韦(cidofovir)可缓解疼痛性棘皮病:病例报告。

Kevin M Burningham, Ritu N Swali, Peter L Rady, Anisha B Patel, Stephen K Tyring
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摘要

目的:棘皮样毛囊炎(TS)是一种罕见的毁容性皮肤病,在免疫力低下的人群中表现为广泛的无症状或瘙痒性皮肤色丘疹,伴有白色突出的角质棘突。由于这种疾病非常罕见,因此几乎没有数据可以指导治疗决策。本文旨在报告一例经西多福韦局部治疗后完全消退的 TS 病例:一名 19 岁的免疫抑制女性,因鼻部和面部出现广泛的痛痒性丘疹而就诊。经检查,面部中央出现红斑丘疹和角化过度的棘皮。活检结果与 TS 一致,并通过 PCR 分析得到证实。该患者糜烂处的触痛在 TS 中非常不典型。医生为其开具了每日一次局部涂抹 1%西多福韦复方乳膏的处方:结果:使用 1%西多福韦酯外用药膏治疗 4 周后,患者的症状完全消失,免疫抑制作用也没有减弱:结论:1%西多福韦外用药膏可能是治疗这种罕见疾病的一种有效方法。
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Resolution of painful trichodysplasia spinulosa with topical cidofovir: case report.

Purpose: Trichodysplasia spinulosa (TS) is a rare, disfiguring skin condition which presents with widespread asymptomatic or pruritic, skin-colored papules with white protruding keratin spiculations in immunocompromised individuals. Due to its rarity, there is little data to guide treatment decisions. The purpose of this article is to report a case of TS that completely resolved after treatment with topical cidofovir.Materials and methods: A 19-year-old immunosuppressed female presented with widespread painful, itchy bumps on the nose and face. Upon examination, there were erythematous papules with hyperkeratinized spicules affecting the central face. Biopsy of the lesions was consistent with TS which was confirmed via PCR analysis. The tenderness of this patient's eruption was highly atypical for TS. Once daily topical application of compounded 1% cidofovir cream was prescribed.Results: The patient's symptoms resolved completely after 4 weeks of therapy with topical cidofovir 1% cream, without reduction of immunosuppression.Conclusions: Topical cidofovir 1% cream may be a valuable treatment for this rare disease.

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