解释糖尿病肾病的性别差异

IF 3.7 3区 医学 Q2 CHEMISTRY, MEDICINAL Chemical Research in Toxicology Pub Date : 2024-03-20 DOI:10.1038/s41574-024-00982-0
Claire Greenhill
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引用次数: 0

摘要

糖尿病肾病(DKD)是糖尿病的常见并发症,可导致慢性肾衰竭。然而,预防和治疗方案相当有限。此外,已知男性和女性患者在糖尿病肾病的发病率和进展率方面存在差异。迄今为止,造成这些性别差异的原因尚不清楚。发表在《科学转化医学》(Science Translational Medicine)上的一项新研究开始了确定DKD性别差异潜在机制的过程。在基线和新陈代谢应激后,男性 PTECs 比女性 PTECs 有更大的细胞表面、更大的线粒体面积、更高的氧消耗率和更高的糖酵解率。两组 PTEC 的最大糖酵解能力、糖酵解储备和 ATP 链接呼吸相似,但雄性细胞的最大呼吸能力和储备能力更强。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Sex differences in diabetic kidney disease explained
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来源期刊
CiteScore
7.90
自引率
7.30%
发文量
215
审稿时长
3.5 months
期刊介绍: Chemical Research in Toxicology publishes Articles, Rapid Reports, Chemical Profiles, Reviews, Perspectives, Letters to the Editor, and ToxWatch on a wide range of topics in Toxicology that inform a chemical and molecular understanding and capacity to predict biological outcomes on the basis of structures and processes. The overarching goal of activities reported in the Journal are to provide knowledge and innovative approaches needed to promote intelligent solutions for human safety and ecosystem preservation. The journal emphasizes insight concerning mechanisms of toxicity over phenomenological observations. It upholds rigorous chemical, physical and mathematical standards for characterization and application of modern techniques.
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