Shuo Li, Yijun Liu, Dan Jiang, Mengyao Liu, Jian Ding, Fei Zhao, Yang Liu, Xia Hu, Xiqin Mao, Qiancheng Zhao
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引用次数: 0
摘要
摘要 本研究的目的是根据中国动物源性食品中农药和兽药最高残留限量标准，建立一种经济有效的提取方法，用于同时测定中国市场上偏好的鲜活水产品中的农药和兽药。建立了QuEChERS-UPLC-MS/MS同时检测39种农药和兽药的方法。结果表明，该方法适用于中国沿海市场6种具有代表性的大宗鲜活水产品，回收率为60.3-119.0%，精密度为4.3-20.8%。实验结果表明，对于鲜活水产品基质，添加EDTA-Mcllvaine可有效提高萃取效率，0.4 g C18/0.4 g PSA/1.2 g MgSO4与正己烷混合萃取3次可有效去除基质干扰。此外，在6种代表性大宗鲜活水产品基质中，39种农药和兽药的LOD和LOQ分别为1.0-5.0 μg/kg和3.0-10.0 μg/kg，为进入市场前的生产质量控制提供了一种实用灵活的筛查方法。
Simultaneous Quantification of 39 Pesticides and Veterinary Drug Residues in Aquaculture Products Using Ultra Performance Liquid Chromatography Tandem Mass Spectrometry with Modified QuEChERS
The aim of this work was to establish a cost-effective extraction procedure for simultaneous determination of pesticides and veterinary drugs in Chinese market preference fresh aquatic products based on MRLs in food of animal origin in China. Modified QuEChERS method coupled to UPLC-MS/MS for the simultaneous detection of 39 pesticides and veterinary drugs were developed. Six representative matrices of bulk fresh aquatic products in China’s coastal markets showed applicability with recoveries 60.3–119.0% and acceptable precision 4.3–20.8%. Experiments showed that for fresh aquatic product matrices, the addition of EDTA-Mcllvaine effectively improved the extraction efficiency, and 0.4-g C18/0.4 g PSA/1.2-g MgSO4 combination with n-hexane extraction three times can remove the matrix interference effectively. Furthermore, LOD and LOQ in the range of 1.0–5.0 μg/kg and 3.0–10.0 μg/kg for 39 pesticides and veterinary drugs upon six representative matrices of bulk fresh aquatic products, respectively, that providing a practical flexible screening method for production quality control before entering the market.
期刊介绍：
Food Analytical Methods publishes original articles, review articles, and notes on novel and/or state-of-the-art analytical methods or issues to be solved, as well as significant improvements or interesting applications to existing methods. These include analytical technology and methodology for food microbial contaminants, food chemistry and toxicology, food quality, food authenticity and food traceability. The journal covers fundamental and specific aspects of the development, optimization, and practical implementation in routine laboratories, and validation of food analytical methods for the monitoring of food safety and quality.
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