分析 2 型糖尿病患者心血管系统对局部加热的振荡过程

IF 4.033 Q4 Biochemistry, Genetics and Molecular Biology Biophysics Pub Date : 2024-03-18 DOI:10.1134/S0006350923060180
I. V. Tikhonova, A. V. Tankanag, I. E. Guseva, A. A. Grinevich
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引用次数: 0

摘要

摘要 对 2 型糖尿病患者局部加热时的心率变异性和四肢皮肤灌注情况进行了全面的光谱分析,并确定了心血管系统病理生理变化的重要预测因素。通过激光多普勒血流测量仪测量了健康人和糖尿病患者静息和局部加热时的心电图以及前臂和足部的皮肤血流灌注情况。对激光多普勒血流测量信号和心率变异性(根据心电图数据)进行了小波分析。使用接收器操作特性分析来评估重要的预测因素。结果发现,与健康人相比,患者(1)加热时足部皮肤血流储备减少;(2)静息和加热时心率振荡幅度减小、(3) 在静止和加热条件下,前臂上的激光多普勒血流测量仪信号在呼吸间歇和心动间歇的振荡幅度增大;以及 (4) 在静止和加热条件下,脚上的激光多普勒血流测量仪信号在肌源性间歇和心动间歇的振荡幅度减小。结果显示,心血管系统参数(低频间歇的心率变异能量和呼吸间歇的前臂激光多普勒血流测量信号振荡,可作为早期诊断微血管疾病的标记)对局部加热的反应具有很高的鉴别力,可区分病人和健康人。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Analysis of Oscillatory Processes in the Cardiovascular System in Response to Local Heating in Patients with Type 2 Diabetes Mellitus

A comprehensive spectral analysis of heart rate variability and skin perfusion of the extremities in patients with type 2 diabetes mellitus in response to local heating and identification of significant predictors of pathophysiological changes in the cardiovascular system has been carried out. Electrocardiogram and skin perfusion on the forearm and foot were measured by laser Doppler flowmetry at rest and under local heating in healthy individuals and diabetic patients. The signals of laser Doppler flowmetry and heart rate variability (according to electrocardiographic data) were subjected to wavelet analysis. Receiver operating characteristic analysis was used to evaluate significant predictors. It was found that in patients, compared with healthy individuals, there was (1) a decrease in the reserve of cutaneous blood flow on the foot under heating, (2) a decrease in the amplitudes of heart rate oscillations at rest and under heating, (3) an increase in the amplitudes of oscillations of laser Doppler flowmetry signals on the forearm in respiratory intervals and cardiac intervals at rest and under heating, and (4) a decrease in the amplitudes of oscillations of laser Doppler flowmetry signals on the foot in the myogenic interval at rest and in the cardiac interval under heating. The parameters of the cardiovascular system (the energy of heart rate variability in the low frequency interval and oscillations of laser Doppler flowmetry signals on the forearm in respiratory interval, which can serve as markers for early diagnosis of microvascular disorders) with high discriminatory power to distinguish patients and healthy individuals in response to local heating were revealed.

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来源期刊
Biophysics
Biophysics Biochemistry, Genetics and Molecular Biology-Biophysics
CiteScore
1.20
自引率
0.00%
发文量
67
期刊介绍: Biophysics is a multidisciplinary international peer reviewed journal that covers a wide scope of problems related to the main physical mechanisms of processes taking place at different organization levels in biosystems. It includes structure and dynamics of macromolecules, cells and tissues; the influence of environment; energy transformation and transfer; thermodynamics; biological motility; population dynamics and cell differentiation modeling; biomechanics and tissue rheology; nonlinear phenomena, mathematical and cybernetics modeling of complex systems; and computational biology. The journal publishes short communications devoted and review articles.
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