GSTT1 空基因多态性对冠心病的潜在影响:一项在南印度队列中进行的试点研究。

IF 1.4 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Indian heart journal Pub Date : 2024-03-01 DOI:10.1016/j.ihj.2024.03.002
Pranesh Rajamuthiah , Sabari Krishnan B B , Sharon Benita Antony , Teena Koshy
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引用次数: 0

摘要

背景:众所周知,印度人罹患冠状动脉疾病(CAD)的比例最高,而传统的风险因素无法解释这种风险的增加。研究与 CAD 相关的环境和遗传风险的可能候选基因是谷胱甘肽 S-转移酶(GST)家族,因为它参与解毒:该病例对照评估了印度 CAD 患者中 GSTM1 和 GSTT1 多态性之间的关联。通过聚合酶链反应对 50 名 CAD 患者和 50 名健康志愿者进行了这两种多态性的基因分型。比较两组之间的基因型频率,P 值小于 0.05 即为具有统计学意义:结果:GSTT1 空多态性与 CAD 易感性之间存在明显的反相关性。
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The potential influence of GSTT1 null genetic polymorphism on coronary artery disease: A pilot study in a South Indian cohort

Background

Indians are known to have the highest rates of coronary artery disease (CAD), with the conventional risk factors failing to explain the increased risk. Possible candidate genes to study both the environmental and genetic risk associated with CAD is the glutathione S-transferase (GST) family, as it is involved in detoxification.

Methods

This case–control assessed the association between GSTM1 and GSTT1 polymorphisms in Indian patients with CAD. Fifty patients with CAD and 50 healthy volunteers were genotyped for the two polymorphisms by polymerase chain reaction. The genotype frequencies between the groups were compared, where a p-value of less than 0.05 was considered as statistically significant.

Results

There was a significant inverse association between GSTT1 null polymorphism and CAD susceptibility.

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来源期刊
Indian heart journal
Indian heart journal CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
2.60
自引率
6.70%
发文量
82
审稿时长
52 days
期刊介绍: Indian Heart Journal (IHJ) is the official peer-reviewed open access journal of Cardiological Society of India and accepts articles for publication from across the globe. The journal aims to promote high quality research and serve as a platform for dissemination of scientific information in cardiology with particular focus on South Asia. The journal aims to publish cutting edge research in the field of clinical as well as non-clinical cardiology - including cardiovascular medicine and surgery. Some of the topics covered are Heart Failure, Coronary Artery Disease, Hypertension, Interventional Cardiology, Cardiac Surgery, Valvular Heart Disease, Pulmonary Hypertension and Infective Endocarditis. IHJ open access invites original research articles, research briefs, perspective, case reports, case vignette, cardiovascular images, cardiovascular graphics, research letters, correspondence, reader forum, and interesting photographs, for publication. IHJ open access also publishes theme-based special issues and abstracts of papers presented at the annual conference of the Cardiological Society of India.
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