器官再生无需依赖再生专用干细胞。

Q4 Biochemistry, Genetics and Molecular Biology Results and Problems in Cell Differentiation Pub Date : 2024-01-01 DOI:10.1007/978-3-031-39027-2_6

Hisato Kondoh

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引用次数: 0

摘要

组织再生的经典概念假定存在组织再生干细胞，这些干细胞在正常组织发育过程中被搁置，作为再生干细胞保留下来。然而，利用细胞追踪和其他方法进行的现代研究已经排除了脊椎动物组织再生中大多数情况下存在再生专用干细胞的可能性。唯一经实验验证的再生专用储备细胞是骨骼肌中的卫星细胞（如米歇尔 2022）（见第 5.2.3 节）。在此，我们将首先讨论大规模组织再生、哺乳动物肝脏再生以及蝾螈晶状体和肢体再生的实例。然后，我们将回顾利用外源转录因子基因扩大哺乳动物组织再生能力的尝试。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Organ Regeneration Without Relying on Regeneration-Dedicated Stem Cells.

The classic conception of tissue regeneration assumed the existence of tissue-proper regeneration stem cells that are set aside during normal tissue development and reserved as stem cells for regeneration. However, modern studies using cell tracing and other approaches have ruled out the presence of regeneration-proper stem cells in most cases in vertebrate tissue regeneration. The only experimentally validated regeneration-dedicated reserve cells are the satellite cells in skeletal muscle (e.g., Michele 2022) (see Sect. 5.2.3 ). Here, we will first discuss examples of large-scale tissue regeneration, liver regeneration in mammals, and lens and limb regeneration in newts. Then, attempts to widen the tissue regeneration capacity in mammals with exogenous transcription factor genes will be reviewed.

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来源期刊

Results and Problems in Cell Differentiation Biochemistry, Genetics and Molecular Biology-Developmental Biology

CiteScore

1.90

自引率

0.00%

发文量

期刊介绍： Results and Problems in Cell Differentiation is an up-to-date book series that presents and explores selected questions of cell and developmental biology. Each volume focuses on a single, well-defined topic. Reviews address basic questions and phenomena, but also provide concise information on the most recent advances. Together, the volumes provide a valuable overview of this exciting and dynamically expanding field.

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