上胚层和多能干细胞系。

Q4 Biochemistry, Genetics and Molecular Biology Results and Problems in Cell Differentiation Pub Date : 2024-01-01 DOI:10.1007/978-3-031-39027-2_1
Hisato Kondoh
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引用次数: 0

摘要

所有体细胞都从上胚层发育而来,上胚层位于两层胚胎的上层,在大多数哺乳动物中,上胚层形成于着床阶段之后,但在胃形成开始之前。上胚层建立后,上胚层细胞开始通过大规模细胞重组(即胃形成)发育成各种体细胞。目前已建立了代表胚胎发育不同阶段的不同多能干细胞系:小鼠胚胎干细胞(mESCs)、人类胚胎干细胞(hESCs)和小鼠上胚层干细胞(EpiSCs),它们分别代表着植入前阶段的内细胞团、植入后早期阶段的上胚层和后期阶段的上胚层。这些细胞系共同为体细胞发育前的细胞调控提供了绝佳的体外模型。本章将讨论这些早期发育阶段。
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The Epiblast and Pluripotent Stem Cell Lines.

All somatic cells develop from the epiblast, which occupies the upper layer of two-layered embryos and in most mammals is formed after the implantation stage but before gastrulation initiates. Once the epiblast is established, the epiblast cells begin to develop into various somatic cells via large-scale cell reorganization, namely, gastrulation. Different pluripotent stem cell lines representing distinct stages of embryogenesis have been established: mouse embryonic stem cells (mESCs), human embryonic stem cells (hESCs), and mouse epiblast stem cells (EpiSCs), which represent the preimplantation stage inner cell mass, an early  post-implantation stage epiblast, and a later-stage epiblast, respectively. Together, these cell lines provide excellent in vitro models of cell regulation before somatic cells develop. This chapter addresses these early developmental stages.

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来源期刊
Results and Problems in Cell Differentiation
Results and Problems in Cell Differentiation Biochemistry, Genetics and Molecular Biology-Developmental Biology
CiteScore
1.90
自引率
0.00%
发文量
21
期刊介绍: Results and Problems in Cell Differentiation is an up-to-date book series that presents and explores selected questions of cell and developmental biology. Each volume focuses on a single, well-defined topic. Reviews address basic questions and phenomena, but also provide concise information on the most recent advances. Together, the volumes provide a valuable overview of this exciting and dynamically expanding field.
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