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引用次数: 0
摘要
以成纤维细胞为目标的 PET 探针经常被用于肿瘤学的各种应用中。近年来,其临床应用范围已扩展到心血管医学领域,如心肌梗塞后、主动脉狭窄或作为动脉粥样硬化的非侵入性读出。在此,我们将简要概述这种 PET 放射性示踪剂在心血管疾病方面的应用现状,包括转化和临床证据。此外,我们还将简要讨论未来的应用,例如使用成纤维细胞靶向 PET 研究心肾轴的双侧器官功能。
PET probes targeting fibroblasts are frequently used for varying applications in oncology. In recent years, the clinical spectrum has been expanded towards cardiovascular medicine, e.g., after myocardial infarction, in aortic stenosis or as a non-invasive read-out of atherosclerosis. We herein provide a brief overview of the current status of this PET radiotracer in the context of cardiovascular disease, including translational and clinical evidence. In addition, we will also briefly discuss future applications, e.g., the use of fibroblast-targeting PET to investigate bilateral organ function along the cardiorenal axis.
期刊介绍:
Seminars in Nuclear Medicine is the leading review journal in nuclear medicine. Each issue brings you expert reviews and commentary on a single topic as selected by the Editors. The journal contains extensive coverage of the field of nuclear medicine, including PET, SPECT, and other molecular imaging studies, and related imaging studies. Full-color illustrations are used throughout to highlight important findings. Seminars is included in PubMed/Medline, Thomson/ISI, and other major scientific indexes.