Comparison between topical Platelet Rich Plasma and Normal Saline dressing, in conjunction with Total Contact Casting in Treatment of Diabetic Foot Ulcer- a Randomized Control Trial

Introduction Wound care, which includes cleaning and fostering a moist wound healing environment, play a crucial role in the management of diabetic foot ulcers.. Total-contact casts are widely used as the most effective external technique for off-loading plantar ulcers. This study compared the effectiveness of PRP and normal saline dressings in conjunction with TCC. Methods 36 patients with diabetic foot ulcers were divided into two groups using computer generated randomization into PRP and NS groups with 18 patients in each group. The PRP group was given autologous PRP, and the NS group was given wet dressing with NS, following which TCC was applied in each case for off-loading. Follow-up was performed every 15 days for 90 days. In each follow-up measurement and TCC application, the time to heal and PUSH score was used to measure the condition of the wound. Results In the PRP group, the mean wound size 8.28 SD 1.18 and the mean Push tool total 13.44 SD 0.98 at base line which gradually decreased, and finally, on day 90, it was reduced to 0.61 SD 1.20 and 1.89 SD 3.68, respectively. In NS group the mean wound size 8.45 SD 1.13 and mean Push tool total 13.50 SD 0.92 at baseline which was gradually decreased and finally at day 90 it was reduced to 1.58 SD 1.55 and 4.61 SD 4.37 respectively. A significant difference was observed in both groups during the final evaluation. Compared with the NS group, the PRP group showed greater improvement. Conclusion Both autologous PRP and NS are effective in treating DFU, when used along with TCC. However, PRP therapy is better at reducing the healing time and hospital visits.