缺氧对大鼠出生后早期发育过程中氧化代谢的影响

Pub Date : 2023-12-01 DOI:10.1134/s1062360423070056

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引用次数: 0

摘要

摘要在新生大鼠出生后头 7 天的发育过程中测量了其耗氧量（VO2）。在此期间，在常氧条件下，VO2随着体重（M）的增加而增加，而具体耗氧量（Ψ）则略有变化。缺氧（10%氧气，40分钟）导致出生后头4天的VO2下降。之后，低氧条件下的 VO2 变化不大。缺氧影响了异速方程的系数：VO2 = aM k。正常缺氧时系数k等于0.74，缺氧时为1.13，缺氧时系数a低于正常缺氧时。在所研究的发育阶段，缺氧暴露后在常氧条件下的恢复能力有所提高。因此，新生大鼠在出生后 1 周内就会从缺氧敏感性过渡到对缺氧的相对耐受性。

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The Effect of Hypoxia on Oxidative Metabolism in the Early Postnatal Development of Rats

Abstract

The rate of oxygen consumption (VO₂) was measured during the first 7 days of postnatal development of newborn rats. During this period, in normoxia, VO₂ increased with increasing body weight (M), while the specific rate of oxygen consumption (Ψ) changed slightly. Hypoxia (10% O₂ for 40 min) caused a decrease in VO₂ in the first 4 days after birth. Later the change in VO₂ under hypoxia was insignificant. Hypoxia influenced on the coefficients of allometric equation: VO₂ = aM ^k. The coefficient k was equal to 0.74 in normoxia and 1.13 in hypoxia, and the coefficient a in hypoxia was lower than in normoxia. The ability to recover in normoxia after hypoxic exposure increased during the studied period of development. Thus, in newborn rats, the transition from hypoxic sensitivity to relative tolerance to hypoxia occurs within 1 week after birth.

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