[肥胖症药物治疗现状]。

Won Jun Kim
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引用次数: 0

摘要

在韩国,肥胖症及各种并发症的发病率正在迅速上升。虽然改变生活方式是治疗肥胖症的基础,但还需要更有效的治疗手段。最近,肥胖症治疗方面取得了许多进展,包括生活方式的改变以及药物、内窥镜和手术治疗。由于肥胖症的治疗是一个长期的过程,因此首选经证实具有长期疗效和安全性的药物。目前,韩国有四种可长期使用的药物:奥利司他、纳曲酮/布呋pion NR、芬特明/托吡酯胶囊和利拉鲁肽。最近,塞马鲁肽和替齐帕特因其有效性和便利性而备受关注,但这两种药物尚未在韩国上市。此外,这两种药物还存在一些局限性,如停药时的溜溜球效应、长期安全性和成本等。患者和医务人员必须了解每种药物的优点和副作用,以确保成功治疗肥胖症。
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[Current State of Pharmacotherapy in Obesity].

The prevalence of obesity with various complications is increasing rapidly in Korea. Although lifestyle modification is fundamental in obesity treatment, more effective treatment tools are required. Many advances in obesity treatment have been reported recently, including lifestyle modifications and pharmacological, endoscopic, and surgical treatments. Drugs with proven long-term efficacy and safety are preferred because management for obesity treatment is a long-term process. Currently, four medications are available for long-term use in Korea: Orlistat, Naltrexone/bupuropion NR, Phentermine/topiramate capsule, and Liraglutide. Recently, semaglutide and tirzepatide have been attracting attention because of their effectiveness and convenience, but they are not yet available in Korea. In addition, there are limitations such as the yo-yo effect when discontinuing the drug, long-term safety, and cost. Patients and medical staff must be aware of the advantages and side effects of each medication to ensure the successful treatment of obesity.

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