一个表现不典型的疣状肉瘤病病例

Akash Rau, Evien Albazi, Kurt Ashack
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摘要

疣状肉瘤病(Morpheaform verrucous sarcoidosis)是皮肤肉瘤病的一种罕见变异,以皮肤上突出的局部角化斑块为特征。这种病的病因不明,目前的文献资料也很有限。肉样瘤病通常是一种全身性疾病,在非裔美国人中发病率很高,而没有全身性表现的皮肤病则极为罕见。鉴于患者同时患有多种自身免疫和炎症病史,本报告详细介绍了该病症的鉴定过程。文献中仅报道了九例病变型肉样瘤病。该病例表明,如果临床全身症状尚未完全出现,诊断皮肤肉样瘤病的难度很大。由于皮肤病变可模拟多种不同的皮肤病,因此必须与皮肤科、风湿病学和肺病学等多学科合作才能得出正确的诊断。因此,对于出现硬化和糜烂性疣状斑块的患者,医生应考虑将病变形式肉样瘤病列入鉴别诊断。
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A Case of Atypical Presentation of Morpheaform Verrucous Sarcoidosis
Morpheaform verrucous sarcoidosis is a rare variation of cutaneous sarcoidosis that is characterized by prominent, localized keratotic plaques on the skin. The etiology of this condition is unknown, and the current literature is limited. Sarcoidosis is typically a systemic condition with high incidence in the African-American population, and cutaneous presentation without systemic manifestation is exceedingly rare. This report details the challenging identification of this condition given the patient's history of multiple concurrent autoimmune and inflammatory conditions. Only nine cases of morpheaform sarcoidosis have been reported in the literature. This case demonstrates the complexity of diagnosing cutaneous sarcoidosis if the clinical systemic symptoms have not yet fully developed. It is important to take a multi-disciplinary approach with dermatology, rheumatology, and pulmonology to arrive at the correct diagnosis as cutaneous lesions can mimic several different cutaneous dermatoses. Therefore, physicians should consider morpheaform sarcoidosis on the differential in patients who present with indurated and eroded verruciform plaques.
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