解决肿瘤进化问题：系统发生学方法

IF 7.6 Q1 ONCOLOGY Journal of the National Cancer Center Pub Date : 2024-06-01 DOI:10.1016/j.jncc.2024.03.001

Lin Li , Wenqin Xie , Li Zhan , Shaodi Wen , Xiao Luo , Shuangbin Xu , Yantong Cai , Wenli Tang , Qianwen Wang , Ming Li , Zijing Xie , Lin Deng , Hongyuan Zhu , Guangchuang Yu

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引用次数: 0

摘要

癌症的进化动态以其深刻的异质性为特征，需要复杂的工具来全面了解。本综述深入探讨了肿瘤系统发育学，这是一种连接进化生物学与肿瘤学的重要方法，能为癌症的进化轨迹提供无与伦比的洞察力。我们概述了包括研究设计、数据采集和系统发育重建在内的工作流程。值得注意的是，整合不同的数据集是一个变革性的步骤，它提高了进化洞察的深度和广度。有了这种综合视角，肿瘤系统发生学将重新定义我们对癌症进化的理解，并影响治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Resolving tumor evolution: a phylogenetic approach

The evolutionary dynamics of cancer, characterized by its profound heterogeneity, demand sophisticated tools for a holistic understanding. This review delves into tumor phylogenetics, an essential approach bridging evolutionary biology with oncology, offering unparalleled insights into cancer's evolutionary trajectory. We provide an overview of the workflow, encompassing study design, data acquisition, and phylogeny reconstruction. Notably, the integration of diverse data sets emerges as a transformative step, enhancing the depth and breadth of evolutionary insights. With this integrated perspective, tumor phylogenetics stands poised to redefine our understanding of cancer evolution and influence therapeutic strategies.

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