用生物打印肝脏器官增强体外肝脏模型

IF 4.7 3区 工程技术 Q2 ENGINEERING, BIOMEDICAL Current Opinion in Biomedical Engineering Pub Date : 2024-03-13 DOI:10.1016/j.cobme.2024.100531
Zachary Congress , Jun Tae Huh , James Yoo , Sang Jin Lee , Shay Soker
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引用次数: 0

摘要

生物打印肝脏器官组织(LOs)已成为研究患者特异性模型、提高疾病理解能力和整体患者护理水平的重要工具。这些系统由肝脏特异性细胞类型和合适的生物材料组成,以促进打印过程并提供细胞容纳的微环境。喷射、挤压和立体光刻等各种打印技术在打印分辨率、流变特性和生物材料选择方面各有优缺点。利用源自患者的细胞,这些模型有助于开发个性化的体外肝脏模型,从而探索疾病进展和药物疗效。推进肝脏组织特异性可打印生物材料的研究,探索能有效模拟肝脏组织各种功能的设计,将大大加快临床相关模型的开发,增强对患者的护理。
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Augmented in vitro liver models with bioprinted liver organoids

Bioprinted liver organoids (LOs) have emerged as a crucial tool for investigating patient-specific models and enhancing disease comprehension as well as overall patient care. These systems are comprised of liver-specific cell types along with suitable biomaterials to facilitate the printing process and provide a microenvironment for cell accommodation. Various printing technologies, such as jetting, extrusion, and stereolithography, each present distinct advantages and disadvantages concerning printing resolution, rheological properties, and biomaterial selection. Leveraging patient-derived cells, these models facilitate the development of personalized in vitro liver models, enabling the exploration of disease progression and drug efficacy. Advancing research on liver tissue-specific printable biomaterials and exploring designs that can effectively mimic the diverse functions of liver tissue will greatly expedite clinically relevant model development and augment patient care.

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来源期刊
Current Opinion in Biomedical Engineering
Current Opinion in Biomedical Engineering Medicine-Medicine (miscellaneous)
CiteScore
8.60
自引率
2.60%
发文量
59
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